Technology Process of (S)-4-benzyl-3-((S)-3-(4-hydroxyphenyl)-3-(isoxazol-3-yl)propanoyl)oxazolidin-2-one
There total 3 articles about (S)-4-benzyl-3-((S)-3-(4-hydroxyphenyl)-3-(isoxazol-3-yl)propanoyl)oxazolidin-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: di-tert-butyl dicarbonate; dmap; triethylamine / tetrahydrofuran / 60 h / 20 °C / Inert atmosphere
2: boron trichloride - methyl sulfide complex / dichloromethane / 7 h / 0 - 20 °C / Inert atmosphere
With
dmap; di-tert-butyl dicarbonate; boron trichloride - methyl sulfide complex; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ml400501x
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: titanium tetrachloride; N,N-diethyl-N-isopropylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere
1.2: -72 - -10 °C / Inert atmosphere
2.1: di-tert-butyl dicarbonate; dmap; triethylamine / tetrahydrofuran / 60 h / 20 °C / Inert atmosphere
3.1: boron trichloride - methyl sulfide complex / dichloromethane / 7 h / 0 - 20 °C / Inert atmosphere
With
dmap; N,N-diethyl-N-isopropylamine; di-tert-butyl dicarbonate; boron trichloride - methyl sulfide complex; titanium tetrachloride; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ml400501x
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N,N-diethyl-N-isopropylamine; titanium tetrachloride / dichloromethane / 0.75 h / -78 °C
1.2: 4 h / -78 - -72 °C
2.1: dmap; di-tert-butyl dicarbonate; triethylamine / tetrahydrofuran / 60 h / 20 °C
3.1: boron trichloride - methyl sulfide complex / dichloromethane / 7 h / 0 - 20 °C
With
dmap; N,N-diethyl-N-isopropylamine; di-tert-butyl dicarbonate; boron trichloride - methyl sulfide complex; titanium tetrachloride; triethylamine;
In
tetrahydrofuran; dichloromethane;