(S)-4-benzyl-3-((S)-3-(4-hydroxyphenyl)-3-(isoxazol-3-yl)propanoyl)oxazolidin-2-one

Base Information

Chemical Name:(S)-4-benzyl-3-((S)-3-(4-hydroxyphenyl)-3-(isoxazol-3-yl)propanoyl)oxazolidin-2-one
CAS No.:1011531-26-2
Molecular Formula:C₂₂H₂₀N₂O₅
Molecular Weight:392.411
Hs Code.:

Synonyms:(S)-4-benzyl-3-((S)-3-(4-hydroxyphenyl)-3-(isoxazol-3-yl)propanoyl)oxazolidin-2-one

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Chemical Property of (S)-4-benzyl-3-((S)-3-(4-hydroxyphenyl)-3-(isoxazol-3-yl)propanoyl)oxazolidin-2-one

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Technology Process of (S)-4-benzyl-3-((S)-3-(4-hydroxyphenyl)-3-(isoxazol-3-yl)propanoyl)oxazolidin-2-one

There total 3 articles about (S)-4-benzyl-3-((S)-3-(4-hydroxyphenyl)-3-(isoxazol-3-yl)propanoyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1011531-24-0
(S)-4-benzyl-3-((S)-3-(4-(benzyloxy)phenyl)-4-nitrobutanoyl)oxazolidin-2-one

: 1011531-26-2
(S)-4-benzyl-3-((S)-3-(4-hydroxyphenyl)-3-(isoxazol-3-yl)propanoyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: di-tert-butyl dicarbonate; dmap; triethylamine / tetrahydrofuran / 60 h / 20 °C / Inert atmosphere

2: boron trichloride - methyl sulfide complex / dichloromethane / 7 h / 0 - 20 °C / Inert atmosphere

With dmap; di-tert-butyl dicarbonate; boron trichloride - methyl sulfide complex; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ml400501x

Reference yield:

: 132836-66-9
(S)-3-acetyl-4-benzyloxazolidin-2-one

: 1011531-26-2
(S)-4-benzyl-3-((S)-3-(4-hydroxyphenyl)-3-(isoxazol-3-yl)propanoyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium tetrachloride; N,N-diethyl-N-isopropylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

1.2: -72 - -10 °C / Inert atmosphere

2.1: di-tert-butyl dicarbonate; dmap; triethylamine / tetrahydrofuran / 60 h / 20 °C / Inert atmosphere

3.1: boron trichloride - methyl sulfide complex / dichloromethane / 7 h / 0 - 20 °C / Inert atmosphere

With dmap; N,N-diethyl-N-isopropylamine; di-tert-butyl dicarbonate; boron trichloride - methyl sulfide complex; titanium tetrachloride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ml400501x

Reference yield:

: 2982-55-0,169394-83-6
1-benzyloxy-4-(2-nitroethenyl)benzene

: 1011531-26-2
(S)-4-benzyl-3-((S)-3-(4-hydroxyphenyl)-3-(isoxazol-3-yl)propanoyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-diethyl-N-isopropylamine; titanium tetrachloride / dichloromethane / 0.75 h / -78 °C

1.2: 4 h / -78 - -72 °C

2.1: dmap; di-tert-butyl dicarbonate; triethylamine / tetrahydrofuran / 60 h / 20 °C

3.1: boron trichloride - methyl sulfide complex / dichloromethane / 7 h / 0 - 20 °C

With dmap; N,N-diethyl-N-isopropylamine; di-tert-butyl dicarbonate; boron trichloride - methyl sulfide complex; titanium tetrachloride; triethylamine; In tetrahydrofuran; dichloromethane;