methyl 5-[2-(4-ethoxycarbonyl-5-methylfuran-2-yl)-2-hydroxy-1-tosylethyl]-N-methoxymethylpyrrol-3-carboxylate

Base Information

Chemical Name:methyl 5-[2-(4-ethoxycarbonyl-5-methylfuran-2-yl)-2-hydroxy-1-tosylethyl]-N-methoxymethylpyrrol-3-carboxylate
CAS No.:342416-53-9
Molecular Formula:C₂₅H₂₉NO₉S
Molecular Weight:519.573
Hs Code.:

Synonyms:methyl 5-[2-(4-ethoxycarbonyl-5-methylfuran-2-yl)-2-hydroxy-1-tosylethyl]-N-methoxymethylpyrrol-3-carboxylate

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Chemical Property of methyl 5-[2-(4-ethoxycarbonyl-5-methylfuran-2-yl)-2-hydroxy-1-tosylethyl]-N-methoxymethylpyrrol-3-carboxylate

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Technology Process of methyl 5-[2-(4-ethoxycarbonyl-5-methylfuran-2-yl)-2-hydroxy-1-tosylethyl]-N-methoxymethylpyrrol-3-carboxylate

There total 1 articles about methyl 5-[2-(4-ethoxycarbonyl-5-methylfuran-2-yl)-2-hydroxy-1-tosylethyl]-N-methoxymethylpyrrol-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 19615-48-6
5-formyl-2-methyl-furan-3-carboxylic acid ethyl ester

: 155345-18-9
methyl 1-methoxymethyl-5-tosylmethyl-1H-pyrrole-3-carboxylate

: 342416-53-9
methyl 5-[2-(4-ethoxycarbonyl-5-methylfuran-2-yl)-2-hydroxy-1-tosylethyl]-N-methoxymethylpyrrol-3-carboxylate

Guidance literature:: methyl 1-methoxymethyl-5-tosylmethyl-1H-pyrrole-3-carboxylate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - -50 ℃; for 3h;

5-formyl-2-methyl-furan-3-carboxylic acid ethyl ester; In tetrahydrofuran; at -50 ℃; for 1h; Further stages.;
DOI:10.1021/ol015717l

Reference yield: 82.0%

: 342416-53-9
methyl 5-[2-(4-ethoxycarbonyl-5-methylfuran-2-yl)-2-hydroxy-1-tosylethyl]-N-methoxymethylpyrrol-3-carboxylate

: 342416-54-0
methyl 5-[2-(4-ethoxycarbonyl-5-methylfuran-2-yl)-2-oxo-1-tosylethyl]-N-methoxymethylpyrrol-3-carboxylate

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In chlorobenzene; for 2h; Heating;
DOI:10.1021/ol015717l

Reference yield:

: 342416-53-9
methyl 5-[2-(4-ethoxycarbonyl-5-methylfuran-2-yl)-2-hydroxy-1-tosylethyl]-N-methoxymethylpyrrol-3-carboxylate

: 4-hydroxy-2-methyl-5-(toluene-4-sulfonyl)-6H-3-oxa-6-aza-as-indacene-1,8-dicarboxylic acid 1-ethyl ester 8-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / DDQ / chlorobenzene / 2 h / Heating

2: 97 percent / Et₃N / CH₂Cl₂ / 3 h / -40 - -10 °C

3: 91 percent / I₂; propylene oxide / benzene / 1 h / Irradiation

4: 96 percent / formic acid / 20 h / 20 °C

5: 22 percent / Mg / methanol / 1 h / 20 °C

With formic acid; iodine; magnesium; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; methyloxirane; In methanol; dichloromethane; chlorobenzene; benzene;
DOI:10.1021/ol015717l