N₄-(3-(difluoromethoxy)phenyl)-N₂-(4-methoxyphenyl)-6-(piperidin-1-yl)pyrim-idine-2,4-diamine

Base Information

• Chemical Name: N₄-(3-(difluoromethoxy)phenyl)-N₂-(4-methoxyphenyl)-6-(piperidin-1-yl)pyrim-idine-2,4-diamine
• CAS No.: 1350641-26-7
• Molecular Formula: C₂₃H₂₅F₂N₅O₂
• Molecular Weight: 441.481

Synonyms:N₄-(3-(difluoromethoxy)phenyl)-N₂-(4-methoxyphenyl)-6-(piperidin-1-yl)pyrim-idine-2,4-diamine

Chemical Property of N₄-(3-(difluoromethoxy)phenyl)-N₂-(4-methoxyphenyl)-6-(piperidin-1-yl)pyrim-idine-2,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N₄-(3-(difluoromethoxy)phenyl)-N₂-(4-methoxyphenyl)-6-(piperidin-1-yl)pyrim-idine-2,4-diamine

There total 3 articles about N₄-(3-(difluoromethoxy)phenyl)-N₂-(4-methoxyphenyl)-6-(piperidin-1-yl)pyrim-idine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H19ClN4O (1355676-73-1) + 3-[(difluoromethyl)oxy]aniline (22236-08-4) → N4-(3-(difluoromethoxy)phenyl)-N2-(4-methoxyphenyl)-6-(piperidin-1-yl)pyrim-idine-2,4-diamine (1350641-26-7)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 85 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.09.033

Reference yield:

piperidine (110-89-4) → N4-(3-(difluoromethoxy)phenyl)-N2-(4-methoxyphenyl)-6-(piperidin-1-yl)pyrim-idine-2,4-diamine (1350641-26-7)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / 0.5 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / butan-1-ol

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 85 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; triethylamine; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; butan-1-ol; 3: Buchwald-Hartwig coupling;

DOI:10.1016/j.bmcl.2011.09.033

Reference yield:

2,4-dichloro-6-(piperidin-1-yl)pyrimidine (213201-98-0) → N4-(3-(difluoromethoxy)phenyl)-N2-(4-methoxyphenyl)-6-(piperidin-1-yl)pyrim-idine-2,4-diamine (1350641-26-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / butan-1-ol

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 85 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; butan-1-ol; 2: Buchwald-Hartwig coupling;

DOI:10.1016/j.bmcl.2011.09.033

upstream raw materials:

piperidine

C₁₆H₁₉ClN₄O

3-[(difluoromethyl)oxy]aniline

2,4-dichloro-6-(piperidin-1-yl)pyrimidine

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