tert-butyl [5-(benzylamino)-4-(benzyloxy)-7-oxo-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate

Base Information

Chemical Name:tert-butyl [5-(benzylamino)-4-(benzyloxy)-7-oxo-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate
CAS No.:1268383-28-3
Molecular Formula:C₂₆H₂₈N₆O₄
Molecular Weight:488.546
Hs Code.:

Synonyms:tert-butyl [5-(benzylamino)-4-(benzyloxy)-7-oxo-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate

Suppliers and Price of tert-butyl [5-(benzylamino)-4-(benzyloxy)-7-oxo-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl [5-(benzylamino)-4-(benzyloxy)-7-oxo-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl [5-(benzylamino)-4-(benzyloxy)-7-oxo-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate

There total 11 articles about tert-butyl [5-(benzylamino)-4-(benzyloxy)-7-oxo-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1268383-06-7
tert-Butyl [5-(benzyloxy)-4-(di-tert butylaminodicarbonate)1,2-dihydro-1-(3-propanal)-2-oxopyrimido[4,5-d]pyrimidin-7-yl]-N-(methyl)carbamate

: 100-46-9
benzylamine

: 1268383-28-3
tert-butyl [5-(benzylamino)-4-(benzyloxy)-7-oxo-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate

: 1268383-04-5
C₂₉H₃₈N₆O₈

Guidance literature:: In 1,2-dichloro-ethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.tetlet.2010.11.122

Reference yield:

: 1268383-20-5
4-(but-3-enylamino)-6-chloro-2-(methylamino)pyrimidine-5-carbaldehyde

: 1268383-28-3
tert-butyl [5-(benzylamino)-4-(benzyloxy)-7-oxo-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydride / tetrahydrofuran / 0 °C / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: dmap; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; potassium hydrogencarbonate / methanol / 0 °C / Inert atmosphere; Reflux

4.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

5.1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

6.1: ammonia / methanol / 2 h / 0 °C / Inert atmosphere

7.1: dmap; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

8.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone; tert-butyl alcohol / 20 °C

9.1: sodium periodate / dichloromethane; water / 20 °C

10.1: 1,2-dichloro-ethane / 24 h / 20 °C / Inert atmosphere

With dmap; sodium periodate; osmium(VIII) oxide; hydroxylamine hydrochloride; ammonia; sodium hydride; potassium hydrogencarbonate; 4-methylmorpholine N-oxide; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; acetone; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2010.11.122

Reference yield:

: 1268383-21-6
4-(benzyloxy)-6-(but-3-enylamino)-2-(methylamino)pyrimidine-5-carbaldehyde

: 1268383-28-3
tert-butyl [5-(benzylamino)-4-(benzyloxy)-7-oxo-7,8-dihydropyrimido[4,5-d]pyrimidin-2-yl]-N-(methyl)carbamate

Guidance literature:: Multi-step reaction with 9 steps

1: dmap; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

2: hydroxylamine hydrochloride; potassium hydrogencarbonate / methanol / 0 °C / Inert atmosphere; Reflux

3: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

4: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

5: ammonia / methanol / 2 h / 0 °C / Inert atmosphere

6: dmap; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

7: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone; tert-butyl alcohol / 20 °C

8: sodium periodate / dichloromethane; water / 20 °C

9: 1,2-dichloro-ethane / 24 h / 20 °C / Inert atmosphere

With dmap; sodium periodate; osmium(VIII) oxide; hydroxylamine hydrochloride; ammonia; potassium hydrogencarbonate; 4-methylmorpholine N-oxide; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; acetone; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2010.11.122