(2,5-difluoro-4-(8-azaspiro[bicyclo[3.2.1]octane-3,2'-[1,3]dioxolane]-8-yl)phenyl)methanamine

Base Information

Chemical Name:(2,5-difluoro-4-(8-azaspiro[bicyclo[3.2.1]octane-3,2'-[1,3]dioxolane]-8-yl)phenyl)methanamine
CAS No.:946388-41-6
Molecular Formula:C₁₆H₂₀F₂N₂O₂
Molecular Weight:310.344
Hs Code.:

Synonyms:(2,5-difluoro-4-(8-azaspiro[bicyclo[3.2.1]octane-3,2'-[1,3]dioxolane]-8-yl)phenyl)methanamine

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Chemical Property of (2,5-difluoro-4-(8-azaspiro[bicyclo[3.2.1]octane-3,2'-[1,3]dioxolane]-8-yl)phenyl)methanamine

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Technology Process of (2,5-difluoro-4-(8-azaspiro[bicyclo[3.2.1]octane-3,2'-[1,3]dioxolane]-8-yl)phenyl)methanamine

There total 5 articles about (2,5-difluoro-4-(8-azaspiro[bicyclo[3.2.1]octane-3,2'-[1,3]dioxolane]-8-yl)phenyl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 946388-40-5
C₁₆H₁₆F₂N₂O₂

: 946388-41-6
(2,5-difluoro-4-(8-azaspiro[bicyclo[3.2.1]octane-3,2'-[1,3]dioxolane]-8-yl)phenyl)methanamine

Guidance literature:: With borane-THF; In tetrahydrofuran; for 2h; Heating;
DOI:10.1021/jm070276i

Reference yield:

: 13375-57-0
8-azaspiro[bicyclo[3.2.1]octane-3,2'-[1,3]dioxolane]

: 946388-41-6
(2,5-difluoro-4-(8-azaspiro[bicyclo[3.2.1]octane-3,2'-[1,3]dioxolane]-8-yl)phenyl)methanamine

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / dimethylsulfoxide / 4 h / 120 °C

2: 73 percent / BH₃*THF / tetrahydrofuran / 2 h / Heating

With borane-THF; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/jm070276i

Reference yield:

: 32499-64-2
N-carbethoxytropinone

: 946388-41-6
(2,5-difluoro-4-(8-azaspiro[bicyclo[3.2.1]octane-3,2'-[1,3]dioxolane]-8-yl)phenyl)methanamine

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / p-toluenesulfonic acid / toluene / 16 h / Heating

2: 79 percent / hydrazine hydrate; KOH; ethanediol / 2 h / Heating

3: 65 percent / dimethylsulfoxide / 4 h / 120 °C

4: 73 percent / BH₃*THF / tetrahydrofuran / 2 h / Heating

With potassium hydroxide; borane-THF; toluene-4-sulfonic acid; hydrazine hydrate; ethylene glycol; In tetrahydrofuran; dimethyl sulfoxide; toluene;
DOI:10.1021/jm070276i