ethyl cis-1-methyl-4-[(1-{5-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]cyclohexanecarboxylate

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Chemical Name:ethyl cis-1-methyl-4-[(1-{5-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]cyclohexanecarboxylate
CAS No.:1415574-05-8
Molecular Formula:C₂₈H₃₃F₃N₄O₃
Molecular Weight:530.59
Hs Code.:

Synonyms:ethyl cis-1-methyl-4-[(1-{5-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]cyclohexanecarboxylate

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Chemical Property of ethyl cis-1-methyl-4-[(1-{5-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]cyclohexanecarboxylate

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Technology Process of ethyl cis-1-methyl-4-[(1-{5-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]cyclohexanecarboxylate

There total 11 articles about ethyl cis-1-methyl-4-[(1-{5-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1356385-98-2
2-(6-fluoropyridin-3-yl)-5-(trifluoromethyl)-1H-benzo[d]imidazole

: 1415573-57-7
ethyl 1-methyl-4-(piperidin-4-yloxy)cyclohexanecarboxylate

: 1415574-05-8
ethyl cis-1-methyl-4-[(1-{5-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]cyclohexanecarboxylate

Guidance literature:: With sodium hydrogencarbonate; In 1-methyl-pyrrolidin-2-one; at 110 ℃; for 4h;

Reference yield:

: 1489-97-0
ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

: 1415574-05-8
ethyl cis-1-methyl-4-[(1-{5-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 2 h / -78 °C

2.1: hydrogenchloride / water; acetone / 48 h / 20 °C

3.1: sodium tetrahydroborate; methanol / 1.5 h / 0 °C

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 55 °C / Inert atmosphere

5.1: ChiraPak AY-H / Resolution of racemate

6.1: hydrogen; acetic acid / Rh/C / 80 °C / 60006 Torr

7.1: sodium hydrogencarbonate / 1-methyl-pyrrolidin-2-one / 4 h / 110 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; di-isopropyl azodicarboxylate; hydrogen; sodium hydrogencarbonate; acetic acid; triphenylphosphine; lithium diisopropyl amide; Rh/C; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; acetone;

Reference yield:

: 3618-04-0,75877-66-6,17159-80-7
4-hydroxycyclohexyl carboxylic acid ethyl ester

: 1415574-05-8
ethyl cis-1-methyl-4-[(1-{5-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 55 °C

2.1: ChiralPak AD-H / Resolution of racemate

3.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 - 20 °C

4.1: hydrogen; acetic acid / Rh/C / 80 °C / 60006 Torr

5.1: sodium hydrogencarbonate / 1-methyl-pyrrolidin-2-one / 4 h / 110 °C

With n-butyllithium; di-isopropyl azodicarboxylate; hydrogen; sodium hydrogencarbonate; acetic acid; diisopropylamine; triphenylphosphine; Rh/C; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;