1-[2-(4-phenylbutyryl)cyclopent-2-enecarbonyl]pyrrolidine-2(S)-carboxylic amide

Base Information

Chemical Name:1-[2-(4-phenylbutyryl)cyclopent-2-enecarbonyl]pyrrolidine-2(S)-carboxylic amide
CAS No.:725265-86-1
Molecular Formula:C₂₁H₂₆N₂O₃
Molecular Weight:354.449
Hs Code.:

Synonyms:1-[2-(4-phenylbutyryl)cyclopent-2-enecarbonyl]pyrrolidine-2(S)-carboxylic amide

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Chemical Property of 1-[2-(4-phenylbutyryl)cyclopent-2-enecarbonyl]pyrrolidine-2(S)-carboxylic amide

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Technology Process of 1-[2-(4-phenylbutyryl)cyclopent-2-enecarbonyl]pyrrolidine-2(S)-carboxylic amide

There total 8 articles about 1-[2-(4-phenylbutyryl)cyclopent-2-enecarbonyl]pyrrolidine-2(S)-carboxylic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 725265-84-9
1-[2-(4-phenylbutyryl)cyclopent-2-enecarbonyl]pyrrolidine-2(S)-carboxylic acid

: 725265-86-1
1-[2-(4-phenylbutyryl)cyclopent-2-enecarbonyl]pyrrolidine-2(S)-carboxylic amide

Guidance literature:: 1-[2-(4-phenylbutyryl)cyclopent-2-enecarbonyl]pyrrolidine-2(S)-carboxylic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at -10 ℃; for 0.333333h;

With ammonium hydroxide; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm049503w

Reference yield:

: 637-59-2
1-Bromo-3-phenylpropane

: 725265-86-1
1-[2-(4-phenylbutyryl)cyclopent-2-enecarbonyl]pyrrolidine-2(S)-carboxylic amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: Mg; I₂ / diethyl ether / Heating

1.2: 69 percent / diethyl ether / 2 h

2.1: 51 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

3.1: trimethylacetyl chloride; Et₃N / CH₂Cl₂ / 2.5 h / 0 °C

3.2: 77 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

4.1: 94 percent / aq. LiOH / methanol / 20 °C

5.1: EtOCOCl; Et₃N / tetrahydrofuran / 0.33 h / -10 °C

5.2: 86 percent / aq. NH₃ / tetrahydrofuran / 20 °C

With lithium hydroxide; oxalyl dichloride; iodine; chloroformic acid ethyl ester; pivaloyl chloride; magnesium; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm049503w

Reference yield:

: 30758-76-0
(+/-)-2-formylcyclopent-2-enecarboxylic acid

: 725265-86-1
1-[2-(4-phenylbutyryl)cyclopent-2-enecarbonyl]pyrrolidine-2(S)-carboxylic amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: Mg; I₂ / diethyl ether / Heating

1.2: 69 percent / diethyl ether / 2 h

2.1: 51 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

3.1: trimethylacetyl chloride; Et₃N / CH₂Cl₂ / 2.5 h / 0 °C

3.2: 77 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

4.1: 94 percent / aq. LiOH / methanol / 20 °C

5.1: EtOCOCl; Et₃N / tetrahydrofuran / 0.33 h / -10 °C

5.2: 86 percent / aq. NH₃ / tetrahydrofuran / 20 °C

With lithium hydroxide; oxalyl dichloride; iodine; chloroformic acid ethyl ester; pivaloyl chloride; magnesium; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm049503w