C₄₈H₆₂O₉Si

Base Information

• Chemical Name: C₄₈H₆₂O₉Si
• CAS No.: 114299-58-0
• Molecular Formula: C₄₈H₆₂O₉Si
• Molecular Weight: 811.1

Synonyms:C₄₈H₆₂O₉Si

Chemical Property of C₄₈H₆₂O₉Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₈H₆₂O₉Si

There total 28 articles about C₄₈H₆₂O₉Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl 2,2-dimethylglutarate (13051-32-6) → C48H62O9Si (114299-58-0)

Guidance literature:

Multi-step reaction with 26 steps

3: tetrahydrofuran / 0.5 h / -78 °C

4: H₂, quinoline / Lindlar catalyst / benzene / 2 h / 25 °C

5: DMAP / CH₂Cl₂ / 2 h / Heating

6: 35 percent / Pd(PPh₃)4, Et₃N / tetrahydrofuran / 5 h / Heating

7: 25 percent / toluene / 5 h / 220 - 230 °C / in sealed tube

8: 90 percent / OsO₄, Me₃NO, pyridine / 2-methyl-propan-2-ol; H₂O / 18 h / Heating

9: 81 percent / SO₃-pyridine, Et₃N / 20 h / 20 °C

10: 85 percent / NaTeH / ethanol / 0.5 h / 23 °C

11: 87 percent / t-BuNH₃-BH₃ / methanol / 21 h / 23 °C

12: 95 percent / TsOH / benzene / 1 h / 23 °C

13: 94 percent / MCPBA / CH₂Cl₂ / 0.5 h / -25 °C

14: 68 percent / CaCO₃ / toluene / 70 h / Heating

15: 92 percent / LiOMe / tetrahydrofuran / 72 h / 23 °C

16: 89 percent / LiAlH₄ / diethyl ether / 1 h / Heating

17: 90 percent / DMAP / 1,2-dichloro-ethane / 6 h / Heating

18: 83 percent / 1.) OsO₄, 2.) H₂S / 1.) pyridine, 20 deg C, 30 h, 2.) chloroform - dioxane, 23 deg C, 0.5 h

19: 91 percent / NaH / hexamethylphosphoric acid triamide; tetrahydrofuran / 3 h / 23 °C

20: 95 percent / TsOH / CHCl₃; methanol / 0.67 h / 20 °C

21: 96 percent / pyridine / 2 h / 20 °C

22: 95 percent / TsOH / 0.25 h / 20 °C

23: 95 percent / LiAlH₄ / diethyl ether / 0.17 h / 0 °C

24: 78 percent / SO₃-pyridine, Et₃N / dimethylsulfoxide / 16 h / 23 °C

25: 80 percent / tetrahydrofuran / 2 h / -78 - 20 °C

26: 79 percent / MnO₂ / benzene / 3 h / 23 °C

With pyridine; quinoline; dmap; manganese(IV) oxide; osmium(VIII) oxide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogen telluride; pyridine-SO₃ complex; trimethylamine-N-oxide; N-tert-butylaminoborane; hydrogen sulfide; lithium methanolate; hydrogen; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; calcium carbonate; Lindlar's catalyst; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; ethanol; dichloromethane; chloroform; water; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene; tert-butyl alcohol; benzene;

DOI:10.1021/ja00219a058

Reference yield:

4,4-dimethyl-5-(tetrahydro-2H-pyran-2-yloxy)pentanal (141424-11-5) → C48H62O9Si (114299-58-0)

Guidance literature:

Multi-step reaction with 25 steps

2: tetrahydrofuran / 0.5 h / -78 °C

3: H₂, quinoline / Lindlar catalyst / benzene / 2 h / 25 °C

4: DMAP / CH₂Cl₂ / 2 h / Heating

5: 35 percent / Pd(PPh₃)4, Et₃N / tetrahydrofuran / 5 h / Heating

6: 25 percent / toluene / 5 h / 220 - 230 °C / in sealed tube

7: 90 percent / OsO₄, Me₃NO, pyridine / 2-methyl-propan-2-ol; H₂O / 18 h / Heating

8: 81 percent / SO₃-pyridine, Et₃N / 20 h / 20 °C

9: 85 percent / NaTeH / ethanol / 0.5 h / 23 °C

10: 87 percent / t-BuNH₃-BH₃ / methanol / 21 h / 23 °C

11: 95 percent / TsOH / benzene / 1 h / 23 °C

12: 94 percent / MCPBA / CH₂Cl₂ / 0.5 h / -25 °C

13: 68 percent / CaCO₃ / toluene / 70 h / Heating

14: 92 percent / LiOMe / tetrahydrofuran / 72 h / 23 °C

15: 89 percent / LiAlH₄ / diethyl ether / 1 h / Heating

16: 90 percent / DMAP / 1,2-dichloro-ethane / 6 h / Heating

17: 83 percent / 1.) OsO₄, 2.) H₂S / 1.) pyridine, 20 deg C, 30 h, 2.) chloroform - dioxane, 23 deg C, 0.5 h

18: 91 percent / NaH / hexamethylphosphoric acid triamide; tetrahydrofuran / 3 h / 23 °C

19: 95 percent / TsOH / CHCl₃; methanol / 0.67 h / 20 °C

20: 96 percent / pyridine / 2 h / 20 °C

21: 95 percent / TsOH / 0.25 h / 20 °C

22: 95 percent / LiAlH₄ / diethyl ether / 0.17 h / 0 °C

23: 78 percent / SO₃-pyridine, Et₃N / dimethylsulfoxide / 16 h / 23 °C

24: 80 percent / tetrahydrofuran / 2 h / -78 - 20 °C

25: 79 percent / MnO₂ / benzene / 3 h / 23 °C

With pyridine; quinoline; dmap; manganese(IV) oxide; osmium(VIII) oxide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogen telluride; pyridine-SO₃ complex; trimethylamine-N-oxide; N-tert-butylaminoborane; hydrogen sulfide; lithium methanolate; hydrogen; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; calcium carbonate; Lindlar's catalyst; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; ethanol; dichloromethane; chloroform; water; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene; tert-butyl alcohol; benzene;

DOI:10.1021/ja00219a058

Reference yield:

2,2-Dimethyl-4-(3-methyl-5-oxo-2,5-dihydro-furan-2-yl)-butyraldehyde (114273-59-5) → C48H62O9Si (114299-58-0)

Guidance literature:

Multi-step reaction with 24 steps

1: tetrahydrofuran / 0.5 h / -78 °C

2: H₂, quinoline / Lindlar catalyst / benzene / 2 h / 25 °C

3: DMAP / CH₂Cl₂ / 2 h / Heating

4: 35 percent / Pd(PPh₃)4, Et₃N / tetrahydrofuran / 5 h / Heating

5: 25 percent / toluene / 5 h / 220 - 230 °C / in sealed tube

6: 90 percent / OsO₄, Me₃NO, pyridine / 2-methyl-propan-2-ol; H₂O / 18 h / Heating

7: 81 percent / SO₃-pyridine, Et₃N / 20 h / 20 °C

8: 85 percent / NaTeH / ethanol / 0.5 h / 23 °C

9: 87 percent / t-BuNH₃-BH₃ / methanol / 21 h / 23 °C

10: 95 percent / TsOH / benzene / 1 h / 23 °C

11: 94 percent / MCPBA / CH₂Cl₂ / 0.5 h / -25 °C

12: 68 percent / CaCO₃ / toluene / 70 h / Heating

13: 92 percent / LiOMe / tetrahydrofuran / 72 h / 23 °C

14: 89 percent / LiAlH₄ / diethyl ether / 1 h / Heating

15: 90 percent / DMAP / 1,2-dichloro-ethane / 6 h / Heating

16: 83 percent / 1.) OsO₄, 2.) H₂S / 1.) pyridine, 20 deg C, 30 h, 2.) chloroform - dioxane, 23 deg C, 0.5 h

17: 91 percent / NaH / hexamethylphosphoric acid triamide; tetrahydrofuran / 3 h / 23 °C

18: 95 percent / TsOH / CHCl₃; methanol / 0.67 h / 20 °C

19: 96 percent / pyridine / 2 h / 20 °C

20: 95 percent / TsOH / 0.25 h / 20 °C

21: 95 percent / LiAlH₄ / diethyl ether / 0.17 h / 0 °C

22: 78 percent / SO₃-pyridine, Et₃N / dimethylsulfoxide / 16 h / 23 °C

23: 80 percent / tetrahydrofuran / 2 h / -78 - 20 °C

24: 79 percent / MnO₂ / benzene / 3 h / 23 °C

With pyridine; quinoline; dmap; manganese(IV) oxide; osmium(VIII) oxide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogen telluride; pyridine-SO₃ complex; trimethylamine-N-oxide; N-tert-butylaminoborane; hydrogen sulfide; lithium methanolate; hydrogen; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; calcium carbonate; Lindlar's catalyst; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; ethanol; dichloromethane; chloroform; water; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene; tert-butyl alcohol; benzene;

DOI:10.1021/ja00219a058

upstream raw materials:

C₄₈H₆₄O₉Si

dimethyl 2,2-dimethylglutarate

(3aβ,5aβ,6aα,9aα,9bα,9cβ)-Decahydro-1,1,8,8,9c-pentamethyl-6-methylene-5H-furo<4',3',2':4,5>naphtho<1,2-d><1,3>dioxol-5-one

(3aβ,,6aα,9aα,9bβ,9cβ)-1,2,3,3a,6a,9a,9b,9c-Octahydro-1,1,6,8,8,9c-hexamethyl-5H-furo<4',3',2':4,5>naphtho<1,2-d><1,3>dioxol-5-one

Downstream raw materials:

C₄₉H₆₆O₉Si

(±)-forskolin

(+/-)-desacetyl forskolin

(E)-5-(tert-Butyl-diphenyl-silanyloxy)-1-[(3aR,4S,5R,5aS,6R,9aR,9bR)-4,5-dihydroxy-6-(4-methoxy-benzyloxy)-2,2,4,5a,9,9-hexamethyl-decahydro-naphtho[1,2-d][1,3]dioxol-5-yl]-3-methyl-pent-2-en-1-one

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