(2S)-N-trityl-2-amino-3-[2-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]propanoic acid

Base Information

• Chemical Name: (2S)-N-trityl-2-amino-3-[2-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]propanoic acid
• CAS No.: 1350570-97-6
• Molecular Formula: C₃₅H₃₄N₂O₂
• Molecular Weight: 514.667
• Mol file: 1350570-97-6.mol

Synonyms:(2S)-N-trityl-2-amino-3-[2-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]propanoic acid

Chemical Property of (2S)-N-trityl-2-amino-3-[2-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-N-trityl-2-amino-3-[2-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]propanoic acid

There total 1 articles about (2S)-N-trityl-2-amino-3-[2-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-2-amino-3-[2-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]propanoic acid triethylamine salt (1350570-92-1) + trityl chloride (76-83-5) → (2S)-N-trityl-2-amino-3-[2-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]propanoic acid (1350570-97-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In chloroform; at 20 ℃; for 2h;

DOI:10.1021/ol202880y

Reference yield: 58.0%

(2S)-N-trityl-2-amino-3-[2-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]propanoic acid (1350570-97-6) + L-proline methyl ester monohydrochloride (2133-40-6) → C41H43N3O3 (1350570-93-2)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

DOI:10.1021/ol202880y

Reference yield:

(2S)-N-trityl-2-amino-3-[2-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]propanoic acid (1350570-97-6) → C41H43N3O4 (1350570-95-4) + C41H43N3O4 (1350570-94-3)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 72 h / 20 °C

2: 3,3-dimethyldioxirane / dichloromethane; acetone / 3 h / -78 - 20 °C

With 3,3-dimethyldioxirane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.1021/ol202880y

upstream raw materials:

(2S)-2-amino-3-[2-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]propanoic acid triethylamine salt

trityl chloride

Downstream raw materials:

C₄₁H₄₃N₃O₄

C₄₁H₄₃N₃O₄

brevianamide E

C₄₁H₄₃N₃O₃