1-(5-Bromothiophen-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

Base Information

Chemical Name:1-(5-Bromothiophen-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol
CAS No.:1416805-39-4
Molecular Formula:C₁₄H₉BrF₄N₄OS
Molecular Weight:437.215
Hs Code.:

Synonyms:1-(5-Bromothiophen-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

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Chemical Property of 1-(5-Bromothiophen-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

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Technology Process of 1-(5-Bromothiophen-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

There total 4 articles about 1-(5-Bromothiophen-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 288-94-8
1H-tetrazole

: 1443429-39-7
C₁₃H₇BrF₄OS

: 1416805-39-4
1-(5-Bromothiophen-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 8h; Temperature;

Reference yield:

: 1286792-85-5
ethyl 2-(5-bromothiophen-2-yl)-2,2-difluoroacetate

: 1416805-39-4
1-(5-Bromothiophen-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 °C

2.1: diethyl ether / 5 h / -5 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 65 °C

With n-butyllithium; potassium carbonate; In diethyl ether; hexane; N,N-dimethyl-formamide;

Reference yield:

: 1443429-38-6
C₁₂H₅BrF₄OS

: 1416805-39-4
1-(5-Bromothiophen-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 5 h / -5 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 65 °C

With potassium carbonate; In diethyl ether; N,N-dimethyl-formamide;