N-[(R)-3-dodecanoyloxytetradecanoyl]-L-aspartic acid β-benzyl ester

Base Information

Chemical Name:N-[(R)-3-dodecanoyloxytetradecanoyl]-L-aspartic acid β-benzyl ester
CAS No.:346669-98-5
Molecular Formula:C₃₇H₆₁NO₇
Molecular Weight:631.894
Hs Code.:

Synonyms:N-[(R)-3-dodecanoyloxytetradecanoyl]-L-aspartic acid β-benzyl ester

Suppliers and Price of N-[(R)-3-dodecanoyloxytetradecanoyl]-L-aspartic acid β-benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(R)-3-dodecanoyloxytetradecanoyl]-L-aspartic acid β-benzyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[(R)-3-dodecanoyloxytetradecanoyl]-L-aspartic acid β-benzyl ester

There total 5 articles about N-[(R)-3-dodecanoyloxytetradecanoyl]-L-aspartic acid β-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 2177-63-1,25248-99-1
(S)-2-amino-4-(benzyloxy)-4-oxobutanoic acid

: 107856-74-6
C₂₆H₅₀O₄

: 346669-98-5
N-[(R)-3-dodecanoyloxytetradecanoyl]-L-aspartic acid β-benzyl ester

Guidance literature:: C₂₆H₅₀O₄; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -15 ℃; for 0.5h;

(S)-2-amino-4-(benzyloxy)-4-oxobutanoic acid; With triethylamine; In tetrahydrofuran; water; acetonitrile; at 20 ℃;
DOI:10.1021/jm060482a

Reference yield:

: 914499-86-8
benzyl (R)-3-dodecanoyloxytetradecanoate

: 346669-98-5
N-[(R)-3-dodecanoyloxytetradecanoyl]-L-aspartic acid β-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 86 percent / H₂ / Pd/C / ethyl acetate; ethanol / 3 h / 20 °C / atmospheric pressure

2.1: N-methylmorpholine; isobutyl chloroformate / tetrahydrofuran / 0.5 h / -15 °C

2.2: 78 percent / Et₃N / tetrahydrofuran; acetonitrile; H₂O / 20 °C

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate;
DOI:10.1021/jm060482a

Reference yield:

: 28715-21-1,3422-31-9
(R)-3-hydroxytetradecanoic acid

: 346669-98-5
N-[(R)-3-dodecanoyloxytetradecanoyl]-L-aspartic acid β-benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: Et₃N; tetrabutylammonium iodide / ethyl acetate / 18 h / 20 °C

2.1: 31.3 g / pyridine / CH₂Cl₂ / 16 h / 20 °C

3.1: 86 percent / H₂ / Pd/C / ethyl acetate; ethanol / 3 h / 20 °C / atmospheric pressure

4.1: N-methylmorpholine; isobutyl chloroformate / tetrahydrofuran / 0.5 h / -15 °C

4.2: 78 percent / Et₃N / tetrahydrofuran; acetonitrile; H₂O / 20 °C

With 4-methyl-morpholine; pyridine; hydrogen; tetra-(n-butyl)ammonium iodide; triethylamine; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm060482a