(3S,4S)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid [(S)-1-(3,5-bistrifluoromethylphenyl)ethyl]methylamide hydrochloride

Base Information

Chemical Name:(3S,4S)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid [(S)-1-(3,5-bistrifluoromethylphenyl)ethyl]methylamide hydrochloride
CAS No.:1076230-22-2
Molecular Formula:C₂₄H₂₅F₇N₂O*ClH
Molecular Weight:526.925
Hs Code.:

Synonyms:(3S,4S)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid [(S)-1-(3,5-bistrifluoromethylphenyl)ethyl]methylamide hydrochloride

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Chemical Property of (3S,4S)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid [(S)-1-(3,5-bistrifluoromethylphenyl)ethyl]methylamide hydrochloride

Chemical Property:

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Technology Process of (3S,4S)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid [(S)-1-(3,5-bistrifluoromethylphenyl)ethyl]methylamide hydrochloride

There total 8 articles about (3S,4S)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid [(S)-1-(3,5-bistrifluoromethylphenyl)ethyl]methylamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3S,4S)-4-{[(S)-1-(3,5-bistrifluoromethylphenyl)ethyl]methylcarbamoyl}-3-(4-fluoro-2-methylphenyl)piperidine-1-carboxylic acid tert-butyl ester

: 1076230-22-2
(3S,4S)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid [(S)-1-(3,5-bistrifluoromethylphenyl)ethyl]methylamide hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; ethyl acetate; at 50 ℃; for 5h;

Reference yield:

: 497843-21-7
1-benzyl-5-(trifluoromethanesulfonoyloxy)-3,6-dihydro-2H-pyridine-4-carboxylic acid ethyl ester

: 1076230-22-2
(3S,4S)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid [(S)-1-(3,5-bistrifluoromethylphenyl)ethyl]methylamide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 100 °C / Inert atmosphere

2.1: hydrogenchloride / ethyl acetate; hexane / 20 °C

2.2: 20 °C

3.1: triethylamine / acetonitrile / 48 h / 20 °C

4.1: hydrogen; platinum(IV) oxide / acetic acid / 24 h / 20 °C

5.1: sodium methylate / methanol / 5 h / Reflux

5.2: 60 °C

6.1: sodium carbonate / water

6.2: 20 °C

7.1: hydrogenchloride / ethanol; ethyl acetate / 5 h / 50 °C

With hydrogenchloride; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium methylate; sodium carbonate; potassium carbonate; triethylamine; In methanol; ethanol; hexane; water; acetic acid; ethyl acetate; toluene; acetonitrile;

Reference yield:

: 52763-21-0
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

: 1076230-22-2
(3S,4S)-3-(4-fluoro-2-methylphenyl)piperidine-4-carboxylic acid [(S)-1-(3,5-bistrifluoromethylphenyl)ethyl]methylamide hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h

1.2: 2 h / 20 °C / Cooling with ice

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 100 °C / Inert atmosphere

3.1: hydrogenchloride / ethyl acetate; hexane / 20 °C

3.2: 20 °C

4.1: triethylamine / acetonitrile / 48 h / 20 °C

5.1: hydrogen; platinum(IV) oxide / acetic acid / 24 h / 20 °C

6.1: sodium methylate / methanol / 5 h / Reflux

6.2: 60 °C

7.1: sodium carbonate / water

7.2: 20 °C

8.1: hydrogenchloride / ethanol; ethyl acetate / 5 h / 50 °C

With hydrogenchloride; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium methylate; sodium hydride; sodium carbonate; potassium carbonate; triethylamine; In methanol; ethanol; hexane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;