7-(4-{4-[(R)-5-((S)-2-amino-propionyloxymethyl)-2-oxo-oxazolidin-3yl]-2-fluoro-phenoxymethyl}-4-hydroxy-piperidin-1-yl)-1-cyclopropyl-6-fluoro-4oxo-1,4-dihydro-quinoline-3-carboxylic acid hydrochloride

Base Information

Chemical Name:7-(4-{4-[(R)-5-((S)-2-amino-propionyloxymethyl)-2-oxo-oxazolidin-3yl]-2-fluoro-phenoxymethyl}-4-hydroxy-piperidin-1-yl)-1-cyclopropyl-6-fluoro-4oxo-1,4-dihydro-quinoline-3-carboxylic acid hydrochloride
CAS No.:1025097-79-3
Molecular Formula:C₃₂H₃₄F₂N₄O₉*ClH
Molecular Weight:693.101
Hs Code.:

7-(4-{4-[(R)-5-((S)-2-amino-propionyloxymethyl)-2-oxo-oxazolidin-3yl]-2-fluoro-phenoxymethyl}-4-hydroxy-piperidin-1-yl)-1-cyclopropyl-6-fluoro-4oxo-1,4-dihydro-quinoline-3-carboxylic acid hydrochloride

Synonyms:7-(4-{4-[(R)-5-((S)-2-amino-propionyloxymethyl)-2-oxo-oxazolidin-3yl]-2-fluoro-phenoxymethyl}-4-hydroxy-piperidin-1-yl)-1-cyclopropyl-6-fluoro-4oxo-1,4-dihydro-quinoline-3-carboxylic acid hydrochloride

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Chemical Property of 7-(4-{4-[(R)-5-((S)-2-amino-propionyloxymethyl)-2-oxo-oxazolidin-3yl]-2-fluoro-phenoxymethyl}-4-hydroxy-piperidin-1-yl)-1-cyclopropyl-6-fluoro-4oxo-1,4-dihydro-quinoline-3-carboxylic acid hydrochloride

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Technology Process of 7-(4-{4-[(R)-5-((S)-2-amino-propionyloxymethyl)-2-oxo-oxazolidin-3yl]-2-fluoro-phenoxymethyl}-4-hydroxy-piperidin-1-yl)-1-cyclopropyl-6-fluoro-4oxo-1,4-dihydro-quinoline-3-carboxylic acid hydrochloride

There total 9 articles about 7-(4-{4-[(R)-5-((S)-2-amino-propionyloxymethyl)-2-oxo-oxazolidin-3yl]-2-fluoro-phenoxymethyl}-4-hydroxy-piperidin-1-yl)-1-cyclopropyl-6-fluoro-4oxo-1,4-dihydro-quinoline-3-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.7%

: 1025097-69-1
7-(4-{4-[(R)-5-((S)-2-tert-butoxycarbonylamino-propionyloxymethyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxymethyl}-4-hydroxy-piperidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

: 1025097-79-3
7-(4-{4-[(R)-5-((S)-2-amino-propionyloxymethyl)-2-oxo-oxazolidin-3yl]-2-fluoro-phenoxymethyl}-4-hydroxy-piperidin-1-yl)-1-cyclopropyl-6-fluoro-4oxo-1,4-dihydro-quinoline-3-carboxylic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 14h;

Reference yield:

: 790703-49-0
(R)-3-(4-benzyloxy-3-fluoro-phenyl)-5-(hydroxymethyl)-oxazolidin-2-one

: 1025097-79-3
7-(4-{4-[(R)-5-((S)-2-amino-propionyloxymethyl)-2-oxo-oxazolidin-3yl]-2-fluoro-phenoxymethyl}-4-hydroxy-piperidin-1-yl)-1-cyclopropyl-6-fluoro-4oxo-1,4-dihydro-quinoline-3-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol

2: sodium carbonate / N,N-dimethyl-formamide / 100 °C

3: hydrogen / palladium on activated charcoal / methanol; ethyl acetate / 48 h

4: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 5 h / 85 °C

5: potassium carbonate / N,N-dimethyl-formamide / 48 h / 80 °C

6: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

7: hydrogen / palladium 10% on activated carbon / 1,4-dioxane; methanol / 4 h

8: hydrogenchloride / 1,4-dioxane / 14 h / 20 °C

With hydrogenchloride; dmap; hydrogen; sodium carbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1025097-50-0
(R)‐3‐(3‐fluoro‐4‐hydroxyphenyl)‐5‐(hydroxymethyl)oxazolidin‐2‐one

: 1025097-79-3
7-(4-{4-[(R)-5-((S)-2-amino-propionyloxymethyl)-2-oxo-oxazolidin-3yl]-2-fluoro-phenoxymethyl}-4-hydroxy-piperidin-1-yl)-1-cyclopropyl-6-fluoro-4oxo-1,4-dihydro-quinoline-3-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: sodium carbonate / N,N-dimethyl-formamide / 100 °C

2: hydrogen / palladium on activated charcoal / methanol; ethyl acetate / 48 h

3: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 5 h / 85 °C

4: potassium carbonate / N,N-dimethyl-formamide / 48 h / 80 °C

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

6: hydrogen / palladium 10% on activated carbon / 1,4-dioxane; methanol / 4 h

7: hydrogenchloride / 1,4-dioxane / 14 h / 20 °C

With hydrogenchloride; dmap; hydrogen; sodium carbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; palladium on activated charcoal; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethyl acetate; N,N-dimethyl-formamide;