(1R,3R,5S,8R)-8-Ethyl-8-methyl-3-(2-phenyl-cyclohex-2-enecarbonyloxy)-8-azonia-bicyclo[3.2.1]octane; bromide

Base Information

• Chemical Name: (1R,3R,5S,8R)-8-Ethyl-8-methyl-3-(2-phenyl-cyclohex-2-enecarbonyloxy)-8-azonia-bicyclo[3.2.1]octane; bromide
• CAS No.: 145449-85-0
• Molecular Formula: Br*C₂₃H₃₂NO₂
• Molecular Weight: 434.417
• Mol file: 145449-85-0.mol

Synonyms:(1R,3R,5S,8R)-8-Ethyl-8-methyl-3-(2-phenyl-cyclohex-2-enecarbonyloxy)-8-azonia-bicyclo[3.2.1]octane; bromide

Chemical Property of (1R,3R,5S,8R)-8-Ethyl-8-methyl-3-(2-phenyl-cyclohex-2-enecarbonyloxy)-8-azonia-bicyclo[3.2.1]octane; bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3R,5S,8R)-8-Ethyl-8-methyl-3-(2-phenyl-cyclohex-2-enecarbonyloxy)-8-azonia-bicyclo[3.2.1]octane; bromide

There total 2 articles about (1R,3R,5S,8R)-8-Ethyl-8-methyl-3-(2-phenyl-cyclohex-2-enecarbonyloxy)-8-azonia-bicyclo[3.2.1]octane; bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

methyl bromide (74-83-9) + endo-8-ethyl-8-azabicyclo<3.2.1>oct-3-yl 2-phenyl-2-cyclohexene-1-carboxylate (145449-83-8) → (1R,3R,5S,8R)-8-Ethyl-8-methyl-3-(2-phenyl-cyclohex-2-enecarbonyloxy)-8-azonia-bicyclo[3.2.1]octane; bromide (145449-85-0)

Guidance literature:

In acetonitrile; at 50 ℃; for 3h;

DOI:10.1016/0223-5234(92)90179-5

Reference yield:

2-phenyl-2-cyclohexene-1-carbonyl chloride (145450-39-1) → (1R,3R,5S,8R)-8-Ethyl-8-methyl-3-(2-phenyl-cyclohex-2-enecarbonyloxy)-8-azonia-bicyclo[3.2.1]octane; bromide (145449-85-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / triethylamine / 1,2-dichloro-ethane / 9 h / Heating

2: 65 percent / acetonitrile / 3 h / 50 °C

With triethylamine; In 1,2-dichloro-ethane; acetonitrile;

DOI:10.1016/0223-5234(92)90179-5

upstream raw materials:

methyl bromide

endo-8-ethyl-8-azabicyclo<3.2.1>oct-3-yl 2-phenyl-2-cyclohexene-1-carboxylate

2-phenyl-2-cyclohexene-1-carbonyl chloride