8-chloro-2-(3-fluorophenyl)-3-(1-hydroxyethyl)pyrrolo[1,2-a]pyrazin-1(2H)-one

Base Information

Chemical Name:8-chloro-2-(3-fluorophenyl)-3-(1-hydroxyethyl)pyrrolo[1,2-a]pyrazin-1(2H)-one
CAS No.:1548340-05-1
Molecular Formula:C₁₅H₁₂ClFN₂O₂
Molecular Weight:306.724
Hs Code.:

Synonyms:8-chloro-2-(3-fluorophenyl)-3-(1-hydroxyethyl)pyrrolo[1,2-a]pyrazin-1(2H)-one

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Chemical Property of 8-chloro-2-(3-fluorophenyl)-3-(1-hydroxyethyl)pyrrolo[1,2-a]pyrazin-1(2H)-one

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Technology Process of 8-chloro-2-(3-fluorophenyl)-3-(1-hydroxyethyl)pyrrolo[1,2-a]pyrazin-1(2H)-one

There total 6 articles about 8-chloro-2-(3-fluorophenyl)-3-(1-hydroxyethyl)pyrrolo[1,2-a]pyrazin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1548340-00-6
8-chloro-3-ethyl-2-(3-fluorophenyl)pyrrolo[1,2-a]pyrazin-1(2H)-one

: 1548340-05-1
8-chloro-2-(3-fluorophenyl)-3-(1-hydroxyethyl)pyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: With selenium(IV) oxide; In 1,4-dioxane; for 1h; Reflux;

Reference yield:

: 226409-94-5
4,4-dichloro-5-(trichloromethyl)-3,4-dihydro-2H-pyrrole

: 1548340-05-1
8-chloro-2-(3-fluorophenyl)-3-(1-hydroxyethyl)pyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 2 h / 20 °C / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 5 °C

2.2: 2 h / 20 °C

3.1: ammonia / methanol / 16 h / 130 °C

4.1: copper diacetate; pyridine / dichloromethane / 16 h / 20 °C / Molecular sieve

5.1: selenium(IV) oxide / 1,4-dioxane / 1 h / Reflux

With pyridine; selenium(IV) oxide; ammonia; copper diacetate; sodium hydride; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1548339-91-8
8-chloro-3-ethylpyrrolo[1,2-a]pyrazin-1(2H)-one

: 1548340-05-1
8-chloro-2-(3-fluorophenyl)-3-(1-hydroxyethyl)pyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: copper diacetate; pyridine / dichloromethane / 16 h / 20 °C / Molecular sieve

2: selenium(IV) oxide / 1,4-dioxane / 1 h / Reflux

With pyridine; selenium(IV) oxide; copper diacetate; In 1,4-dioxane; dichloromethane;