2-[butyl-(2-isopropyl-6-methyl-5-phenylethynylpyrimidin-4-yl)-amino]-N-(4-chlorobenzyl)-2-phenylacetamide

Base Information

• Chemical Name: 2-[butyl-(2-isopropyl-6-methyl-5-phenylethynylpyrimidin-4-yl)-amino]-N-(4-chlorobenzyl)-2-phenylacetamide
• CAS No.: 1236282-98-6
• Molecular Formula: C₃₅H₃₇ClN₄O
• Molecular Weight: 565.158

Synonyms:2-[butyl-(2-isopropyl-6-methyl-5-phenylethynylpyrimidin-4-yl)-amino]-N-(4-chlorobenzyl)-2-phenylacetamide

Chemical Property of 2-[butyl-(2-isopropyl-6-methyl-5-phenylethynylpyrimidin-4-yl)-amino]-N-(4-chlorobenzyl)-2-phenylacetamide

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Technology Process of 2-[butyl-(2-isopropyl-6-methyl-5-phenylethynylpyrimidin-4-yl)-amino]-N-(4-chlorobenzyl)-2-phenylacetamide

There total 1 articles about 2-[butyl-(2-isopropyl-6-methyl-5-phenylethynylpyrimidin-4-yl)-amino]-N-(4-chlorobenzyl)-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

2-[butyl-(5-iodo-2-isopropyl-6-methylpyrimidin-4-yl)-amino]-N-(4-chlorobenzyl)-2-phenylacetamide (1236282-77-1) + phenylacetylene (536-74-3) → 2-[butyl-(2-isopropyl-6-methyl-5-phenylethynylpyrimidin-4-yl)-amino]-N-(4-chlorobenzyl)-2-phenylacetamide (1236282-98-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 70 ℃;

DOI:10.1021/jo100759b

Reference yield: 73.0%

2-[butyl-(2-isopropyl-6-methyl-5-phenylethynylpyrimidin-4-yl)-amino]-N-(4-chlorobenzyl)-2-phenylacetamide (1236282-98-6) → 5-benzylidene-7-butyl-N-(4-chlorobenzyl)-2-isopropyl-4-methyl-6-phenyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (1236283-28-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol;

DOI:10.1021/jo100759b

Reference yield: 65.0%

2-[butyl-(2-isopropyl-6-methyl-5-phenylethynylpyrimidin-4-yl)-amino]-N-(4-chlorobenzyl)-2-phenylacetamide (1236282-98-6) → 5-benzylidene-7-butyl-N-(4-chlorobenzyl)-2-isopropyl-4-methyl-6-phenyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (1236283-28-5) + 5-benzylidene-7-butyl-N-(4-chlorobenzyl)-2-isopropyl-4-methyl-6-phenyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (1236283-30-9)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; optical yield given as %de;

DOI:10.1021/jo100759b

upstream raw materials:

2-[butyl-(5-iodo-2-isopropyl-6-methylpyrimidin-4-yl)-amino]-N-(4-chlorobenzyl)-2-phenylacetamide

phenylacetylene

Downstream raw materials:

5-benzylidene-7-butyl-N-(4-chlorobenzyl)-2-isopropyl-4-methyl-6-phenyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

5-benzylidene-7-butyl-N-(4-chlorobenzyl)-2-isopropyl-4-methyl-6-phenyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

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