(3S,5R,7aS,11aS)-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-hexyloctahydro-pyrrolo-1H-pyrrolo[2,1-j]quinolin-7(7aH)-one

Base Information

Chemical Name:(3S,5R,7aS,11aS)-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-hexyloctahydro-pyrrolo-1H-pyrrolo[2,1-j]quinolin-7(7aH)-one
CAS No.:634613-81-3
Molecular Formula:C₃₅H₅₁NO₂Si
Molecular Weight:545.881
Hs Code.:

Synonyms:(3S,5R,7aS,11aS)-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-hexyloctahydro-pyrrolo-1H-pyrrolo[2,1-j]quinolin-7(7aH)-one

Suppliers and Price of (3S,5R,7aS,11aS)-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-hexyloctahydro-pyrrolo-1H-pyrrolo[2,1-j]quinolin-7(7aH)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (3S,5R,7aS,11aS)-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-hexyloctahydro-pyrrolo-1H-pyrrolo[2,1-j]quinolin-7(7aH)-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,5R,7aS,11aS)-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-hexyloctahydro-pyrrolo-1H-pyrrolo[2,1-j]quinolin-7(7aH)-one

There total 20 articles about (3S,5R,7aS,11aS)-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-hexyloctahydro-pyrrolo-1H-pyrrolo[2,1-j]quinolin-7(7aH)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 634613-79-9
[1-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2-non-2-enoyl-cyclohex-1-enyl)-propyl]-carbamic acid tert-butyl ester

: 634613-81-3
(3S,5R,7aS,11aS)-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-hexyloctahydro-pyrrolo-1H-pyrrolo[2,1-j]quinolin-7(7aH)-one

Guidance literature:: [1-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2-non-2-enoyl-cyclohex-1-enyl)-propyl]-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; for 1h;

With potassium carbonate; In toluene; for 68h; Heating;
DOI:10.1021/ol035752n

Reference yield:

: 791635-36-4
(3S,5R,7aR,11aS)-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-hexyloctahydro-pyrrolo-1H-pyrrolo[2,1-j]quinolin-7(7aH)-one

: 634613-81-3
(3S,5R,7aS,11aS)-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-hexyloctahydro-pyrrolo-1H-pyrrolo[2,1-j]quinolin-7(7aH)-one

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃;
DOI:10.1021/ol048353g

Reference yield:

: 871-84-1
1,7-Octadiyne

: 634613-81-3
(3S,5R,7aS,11aS)-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-hexyloctahydro-pyrrolo-1H-pyrrolo[2,1-j]quinolin-7(7aH)-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: LHMDS / tetrahydrofuran / 0.5 h / -78 °C

1.2: 45 percent / tetrahydrofuran / -78 - 20 °C

2.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C

2.2: 99 percent / tetrahydrofuran / -78 - 20 °C

3.1: 99 percent / NBS; AgNO₃ / dimethylformamide / 3 h / 20 °C

4.1: Zn; dibromoethane; trimethylsilyl chloride / tetrahydrofuran / 3 h / 40 °C

4.2: CuCN; LiCl / tetrahydrofuran / -10 - 0 °C

4.3: 44 percent / tetrahydrofuran / 20 h / -78 °C

5.1: 91 percent / LiBH₄ / tetrahydrofuran / 20 h / 20 °C

6.1: 95 percent / imidazole / dimethylformamide / 3 h

7.1: 90 percent / [CpRu(CH₃CN)3]PF₆ / H₂O; acetone / 2 h / 60 °C

8.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

8.2: tetrahydrofuran / 4 h

8.3: 83 percent / Et₃N; MsCl / CH₂Cl₂ / 20 h / 20 °C

9.1: CF₃CO₂H / CH₂Cl₂ / 1 h

9.2: 90 percent / K₂CO₃ / toluene / 68 h / Heating

With 1H-imidazole; N-Bromosuccinimide; lithium borohydride; n-butyllithium; chloro-trimethyl-silane; 1,1-Dibromoethane; silver nitrate; trifluoroacetic acid; lithium hexamethyldisilazane; zinc; lithium diisopropyl amide; cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol035752n