(2S,3S,4R,5R,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-7-{(1S,2S)-2-[(1S,2R,3S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-1,3-dimethyl-butyl]-cyclopropyl}-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptan-1-ol

Base Information

Chemical Name:(2S,3S,4R,5R,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-7-{(1S,2S)-2-[(1S,2R,3S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-1,3-dimethyl-butyl]-cyclopropyl}-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptan-1-ol
CAS No.:869338-57-8
Molecular Formula:C₄₁H₇₈O₇Si₂
Molecular Weight:739.237
Hs Code.:

(2S,3S,4R,5R,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-7-{(1S,2S)-2-[(1S,2R,3S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-1,3-dimethyl-butyl]-cyclopropyl}-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptan-1-ol

Synonyms:(2S,3S,4R,5R,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-7-{(1S,2S)-2-[(1S,2R,3S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-1,3-dimethyl-butyl]-cyclopropyl}-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptan-1-ol

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Chemical Property of (2S,3S,4R,5R,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-7-{(1S,2S)-2-[(1S,2R,3S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-1,3-dimethyl-butyl]-cyclopropyl}-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptan-1-ol

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Technology Process of (2S,3S,4R,5R,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-7-{(1S,2S)-2-[(1S,2R,3S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-1,3-dimethyl-butyl]-cyclopropyl}-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptan-1-ol

There total 7 articles about (2S,3S,4R,5R,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-7-{(1S,2S)-2-[(1S,2R,3S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-1,3-dimethyl-butyl]-cyclopropyl}-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 869338-36-3
(2S,4S,5S)-4-((1R,2R,3S)-2-(tert-Butyl-dimethyl-silanyloxy)-4-{(1S,2S)-2-[(1S,2R,3S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-1,3-dimethyl-butyl]-cyclopropyl}-1,3-dimethyl-butyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxane

: 869338-57-8
(2S,3S,4R,5R,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-7-{(1S,2S)-2-[(1S,2R,3S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-1,3-dimethyl-butyl]-cyclopropyl}-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptan-1-ol

Guidance literature:: With diisobutylaluminium hydride;
DOI:10.1021/ol051691c

Reference yield:

: 869338-33-0
(2S,3R,4S)-4-((1R,2R)-2-Iodo-cyclopropyl)-3-methoxymethoxy-2-methyl-pentan-1-ol

: 869338-57-8
(2S,3S,4R,5R,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-7-{(1S,2S)-2-[(1S,2R,3S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-1,3-dimethyl-butyl]-cyclopropyl}-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 99 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / -30 °C

2.1: t-BuLi / tetrahydrofuran; pentane / 0.5 h / -78 °C / y

2.2: 2-ThCuCNLi / tetrahydrofuran; pentane / 0.5 h / -78 - -20 °C

2.3: 61 percent / tetrahydrofuran; pentane / 23 h / -40 - 0 °C

3.1: 92 percent / DIBAL

With 2,6-dimethylpyridine; tert.-butyl lithium; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; pentane;
DOI:10.1021/ol051691c

Reference yield:

: 869338-49-8
(Z)-(2S,3R,4S)-6-Iodo-1-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-5-en-3-ol

: 869338-57-8
(2S,3S,4R,5R,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-7-{(1S,2S)-2-[(1S,2R,3S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-1,3-dimethyl-butyl]-cyclopropyl}-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 71 percent / Et₂Zn / 1,2-dichloro-ethane / 3 h / 20 °C

2.1: 95 percent / i-Pr₂NEt / CH₂Cl₂ / 24 h / 20 °C

3.1: 90 percent / DDQ; H₂O / CH₂Cl₂ / 0 - 20 °C

4.1: 99 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / -30 °C

5.1: t-BuLi / tetrahydrofuran; pentane / 0.5 h / -78 °C / y

5.2: 2-ThCuCNLi / tetrahydrofuran; pentane / 0.5 h / -78 - -20 °C

5.3: 61 percent / tetrahydrofuran; pentane / 23 h / -40 - 0 °C

6.1: 92 percent / DIBAL

With 2,6-dimethylpyridine; water; tert.-butyl lithium; diethylzinc; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; pentane;
DOI:10.1021/ol051691c