(R)-4-(tert-butyldimethylsilyloxy)-6-(1-phenyl-1H-tetrazol-5-ylthio)hexyl pivalate

Base Information

Chemical Name:(R)-4-(tert-butyldimethylsilyloxy)-6-(1-phenyl-1H-tetrazol-5-ylthio)hexyl pivalate
CAS No.:1417996-05-4
Molecular Formula:C₂₄H₄₀N₄O₃SSi
Molecular Weight:492.758
Hs Code.:

Synonyms:(R)-4-(tert-butyldimethylsilyloxy)-6-(1-phenyl-1H-tetrazol-5-ylthio)hexyl pivalate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-(tert-butyldimethylsilyloxy)-6-(1-phenyl-1H-tetrazol-5-ylthio)hexyl pivalate

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Technology Process of (R)-4-(tert-butyldimethylsilyloxy)-6-(1-phenyl-1H-tetrazol-5-ylthio)hexyl pivalate

There total 4 articles about (R)-4-(tert-butyldimethylsilyloxy)-6-(1-phenyl-1H-tetrazol-5-ylthio)hexyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1417996-04-3
(R)-4-(tert-butyldimethylsilyloxy)-6-hydroxyhexyl pivalate

: 86-93-1
1-Phenyl-1H-tetrazole-5-thiol

: 1417996-05-4
(R)-4-(tert-butyldimethylsilyloxy)-6-(1-phenyl-1H-tetrazol-5-ylthio)hexyl pivalate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201201119

Reference yield:

: 30435-87-1
2,2-dimethylpropionic acid-4-oxo-butyl ester

: 1417996-05-4
(R)-4-(tert-butyldimethylsilyloxy)-6-(1-phenyl-1H-tetrazol-5-ylthio)hexyl pivalate

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium(IV) isopropylate; titanium tetrachloride; (R)-1,1'-Bi-2-naphthol; silver(l) oxide / dichloromethane / 5 h / -15 - 0 °C / Inert atmosphere

2.1: 1H-imidazole; dmap / dichloromethane / 6 h / 20 °C / Inert atmosphere

3.1: ozone / dichloromethane; methanol / -78 °C

3.2: 12 h / -78 - 20 °C / Inert atmosphere

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; titanium(IV) isopropylate; dmap; di-isopropyl azodicarboxylate; (R)-1,1'-Bi-2-naphthol; titanium tetrachloride; ozone; triphenylphosphine; silver(l) oxide; In tetrahydrofuran; methanol; dichloromethane; 4.1: |Mitsunobu Displacement;
DOI:10.1002/ejoc.201201119

Reference yield:

: 1417996-03-2
(R)-4-(tert-butyldimethylsilyloxy)hept-6-enyl pivalate

: 1417996-05-4
(R)-4-(tert-butyldimethylsilyloxy)-6-(1-phenyl-1H-tetrazol-5-ylthio)hexyl pivalate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ozone / dichloromethane; methanol / -78 °C

1.2: 12 h / -78 - 20 °C / Inert atmosphere

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; ozone; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; 2.1: |Mitsunobu Displacement;
DOI:10.1002/ejoc.201201119