(RS)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one

Base Information

Chemical Name:(RS)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one
CAS No.:1266784-31-9
Molecular Formula:C₂₄H₂₁FN₂O₂
Molecular Weight:388.441
Hs Code.:

Synonyms:(RS)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one

Suppliers and Price of (RS)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (RS)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (RS)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one

There total 9 articles about (RS)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1013-88-3
Benzophenone imine

: 1266784-13-7
rac-5-(5-bromo-2-fluorophenyl)-5-methylmorpholin-3-one

: 1266784-31-9
(RS)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one

Guidance literature:: With sodium t-butanolate; tert-butyl XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In toluene;

Reference yield:

: 198477-89-3
1-(5-bromo-2-fluorophenyl)ethan-1-one

: 1266784-31-9
(RS)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one

Guidance literature:: Multi-step reaction with 7 steps

1: ethanol / 16 h / 120 °C / autoclave

2: sodium hydroxide; water

3: thionyl chloride

4: lithium aluminium tetrahydride / tetrahydrofuran

5: acetonitrile

6: potassium tert-butylate

7: sodium t-butanolate; tert-butyl XPhos / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene

With lithium aluminium tetrahydride; thionyl chloride; potassium tert-butylate; water; sodium hydroxide; sodium t-butanolate; tert-butyl XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; ethanol; toluene; acetonitrile;

Reference yield:

: 910912-20-8
5-bromo-2-fluoro-N-methoxy-N-methylbenzamide

: 1266784-31-9
(RS)-5-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-5-methyl-morpholin-3-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran / 0.33 h / 12 - 16 °C / Reflux

1.2: Cooling

2.1: ethanol / 16 h / 120 °C / autoclave

3.1: sodium hydroxide; water

4.1: thionyl chloride

5.1: lithium aluminium tetrahydride / tetrahydrofuran

6.1: acetonitrile

7.1: potassium tert-butylate

8.1: sodium t-butanolate; tert-butyl XPhos / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene

With lithium aluminium tetrahydride; thionyl chloride; potassium tert-butylate; water; sodium hydroxide; sodium t-butanolate; tert-butyl XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; ethanol; toluene; acetonitrile;