Technology Process of 8α-(Phenylseleno)-9β-hydroxy-3-oxo-(7αH,6,11βH)-eudesm-4-en-6,12-olide
There total 5 articles about 8α-(Phenylseleno)-9β-hydroxy-3-oxo-(7αH,6,11βH)-eudesm-4-en-6,12-olide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
titanium(IV) isopropylate; sodium tetrahydroborate; acetic acid;
In
N,N-dimethyl-formamide;
for 25h;
Ambient temperature;
DOI:10.1016/S0040-4039(00)79147-7
- Guidance literature:
-
Multi-step reaction with 5 steps
1: H2 / Wilkinson catalyst / benzene
2: pyridine / CH2Cl2 / 0.5 h / -15 °C
3: Li2CO3 / N,N-dimethyl-acetamide / 0.5 h / 60 °C
4: 99 percent / dimethyl dioxirane / acetone; CH2Cl2 / 9 h / 0 °C
5: 85 percent / NaBH4, AcOH, Ti(i-PrO)4 / dimethylformamide / 25 h / Ambient temperature
With
pyridine; titanium(IV) isopropylate; sodium tetrahydroborate; hydrogen; 3,3-dimethyldioxirane; lithium carbonate; acetic acid;
Wilkinson's catalyst;
In
dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1016/S0040-4039(00)79147-7
- Guidance literature:
-
Multi-step reaction with 4 steps
1: pyridine / CH2Cl2 / 0.25 h / -20 °C
2: Li2CO3, N,N-dimethylacetamide / 0.25 h / 80 °C
3: 100 percent / dimethyloxirane / acetone; CH2Cl2 / 9 h / 0 °C
4: 1.) NaBH4, acetic acid, 2.) Ti(i-PrO)4 / 1.) THF, room temp., 2 h, 2.) DMF, 25 h
With
2-methyl-1,2-epoxypropane; pyridine; titanium(IV) isopropylate; sodium tetrahydroborate; N,N-dimethyl acetamide; lithium carbonate; acetic acid;
In
dichloromethane; acetone;
DOI:10.1021/jo00077a051
