4-[2-(bis-ethoxycarbonylmethyl-amino)-acetylamino]-benzoic acid

Base Information

• Chemical Name: 4-[2-(bis-ethoxycarbonylmethyl-amino)-acetylamino]-benzoic acid
• CAS No.: 796113-60-5
• Molecular Formula: C₁₇H₂₂N₂O₇
• Molecular Weight: 366.371
• Mol file: 796113-60-5.mol

Synonyms:4-[2-(bis-ethoxycarbonylmethyl-amino)-acetylamino]-benzoic acid

Chemical Property of 4-[2-(bis-ethoxycarbonylmethyl-amino)-acetylamino]-benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[2-(bis-ethoxycarbonylmethyl-amino)-acetylamino]-benzoic acid

There total 1 articles about 4-[2-(bis-ethoxycarbonylmethyl-amino)-acetylamino]-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) + 2-(bis(2-ethoxy-2-oxoethyl)amino)acetic acid (174741-52-7) → 4-[2-(bis-ethoxycarbonylmethyl-amino)-acetylamino]-benzoic acid (796113-60-5)

Guidance literature:

2-(bis(2-ethoxy-2-oxoethyl)amino)acetic acid; With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In ethyl acetate; at 20 ℃; for 0.75h;

4-amino-benzoic acid; With triethylamine; In chloroform; at 20 ℃; for 8h;

DOI:10.1021/ja047271k

Reference yield: 63.0%

N-{2-[2-(2-Amino-ethoxy)-ethoxy]-ethyl}-4-sulfamoyl-benzamide; compound with trifluoro-acetic acid + 4-[2-(bis-ethoxycarbonylmethyl-amino)-acetylamino]-benzoic acid (796113-60-5) → (ethoxycarbonylmethyl-{[4-(2-{2-[2-(4-sulfamoyl-benzoylamino)-ethoxy]-ethoxy}-ethylcarbamoyl)-phenylcarbamoyl]-methyl}-amino)-acetic acid ethyl ester

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In chloroform;

DOI:10.1021/ja047271k

Reference yield:

4-[2-(bis-ethoxycarbonylmethyl-amino)-acetylamino]-benzoic acid (796113-60-5) → (carboxymethyl-{[4-(2-{2-[2-(4-sulfamoyl-benzoylamino)-ethoxy]-ethoxy}-ethylcarbamoyl)-phenylcarbamoyl]-methyl}-amino)-acetic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / BOP; Et₃N / CHCl₃

2: 81 percent / LiOH / methanol; CH₂Cl₂

With lithium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In methanol; dichloromethane; chloroform;

DOI:10.1021/ja047271k

upstream raw materials:

4-amino-benzoic acid

2-(bis(2-ethoxy-2-oxoethyl)amino)acetic acid