(2S)-2-tert-butoxy-2-(1-(4-chlorophenyl)-7-(3-(4-fluorophenyl)-3-hydroxybut-1-ynyl)-3-methylnaphthalen-2-yl)acetic acid

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Chemical Name:(2S)-2-tert-butoxy-2-(1-(4-chlorophenyl)-7-(3-(4-fluorophenyl)-3-hydroxybut-1-ynyl)-3-methylnaphthalen-2-yl)acetic acid
CAS No.:1447068-79-2
Molecular Formula:C₃₃H₃₀ClFO₄
Molecular Weight:545.05
Hs Code.:

Synonyms:(2S)-2-tert-butoxy-2-(1-(4-chlorophenyl)-7-(3-(4-fluorophenyl)-3-hydroxybut-1-ynyl)-3-methylnaphthalen-2-yl)acetic acid

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Chemical Property of (2S)-2-tert-butoxy-2-(1-(4-chlorophenyl)-7-(3-(4-fluorophenyl)-3-hydroxybut-1-ynyl)-3-methylnaphthalen-2-yl)acetic acid

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Technology Process of (2S)-2-tert-butoxy-2-(1-(4-chlorophenyl)-7-(3-(4-fluorophenyl)-3-hydroxybut-1-ynyl)-3-methylnaphthalen-2-yl)acetic acid

There total 10 articles about (2S)-2-tert-butoxy-2-(1-(4-chlorophenyl)-7-(3-(4-fluorophenyl)-3-hydroxybut-1-ynyl)-3-methylnaphthalen-2-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1447071-15-9
(2S)-ethyl 2-tert-butoxy-2-(1-(4-chlorophenyl)-7-(3-(4-fluorophenyl)-3-hydroxybut-1-ynyl)-3-methylnaphthalen-2-yl)acetate

: 1447068-79-2
(2S)-2-tert-butoxy-2-(1-(4-chlorophenyl)-7-(3-(4-fluorophenyl)-3-hydroxybut-1-ynyl)-3-methylnaphthalen-2-yl)acetic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; water; at 60 ℃; for 2h;

Reference yield:

: 1354491-92-1
7-bromo-3-methylnaphthalen-1-ol

: 1447068-79-2
(2S)-2-tert-butoxy-2-(1-(4-chlorophenyl)-7-(3-(4-fluorophenyl)-3-hydroxybut-1-ynyl)-3-methylnaphthalen-2-yl)acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: titanium tetrachloride / dichloromethane / 0.33 h / 0 °C

1.2: 1.25 h / 0 °C

2.1: 1H-imidazole; triethylsilyl chloride / dichloromethane / 16 h

2.2: 0.5 h / -78 °C

2.3: 20 °C

3.1: Dess-Martin periodane / dichloromethane / 1.5 h

4.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; toluene; ethanol / 2 h / 20 °C

5.1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole / toluene / 1.25 h / -40 °C

6.1: perchloric acid / water / 3 h

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(l) iodide / tetrahydrofuran / 1 h / 70 °C

8.1: water; sodium hydroxide / tetrahydrofuran; water; methanol / 2 h / 60 °C

With 1H-imidazole; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; perchloric acid; triethylsilyl chloride; water; titanium tetrachloride; potassium carbonate; Dess-Martin periodane; triethylamine; sodium hydroxide; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;

Reference yield:

: 6186-22-7
4-bromophenyl acetone

: 1447068-79-2
(2S)-2-tert-butoxy-2-(1-(4-chlorophenyl)-7-(3-(4-fluorophenyl)-3-hydroxybut-1-ynyl)-3-methylnaphthalen-2-yl)acetic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

1.2: 0 - 23 °C

2.1: sulfuric acid / 2.5 h / 50 °C

3.1: titanium tetrachloride / dichloromethane / 0.33 h / 0 °C

3.2: 1.25 h / 0 °C

4.1: 1H-imidazole; triethylsilyl chloride / dichloromethane / 16 h

4.2: 0.5 h / -78 °C

4.3: 20 °C

5.1: Dess-Martin periodane / dichloromethane / 1.5 h

6.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; toluene; ethanol / 2 h / 20 °C

7.1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole / toluene / 1.25 h / -40 °C

8.1: perchloric acid / water / 3 h

9.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(l) iodide / tetrahydrofuran / 1 h / 70 °C

10.1: water; sodium hydroxide / tetrahydrofuran; water; methanol / 2 h / 60 °C

With 1H-imidazole; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; perchloric acid; triethylsilyl chloride; sulfuric acid; water; titanium tetrachloride; sodium hydride; potassium carbonate; Dess-Martin periodane; triethylamine; sodium hydroxide; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; mineral oil;