(E)-(3R,6R)-6-Benzyl-7-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-cyclohexylmethyl-7-oxo-hept-4-enoic acid ethyl ester

Base Information

• Chemical Name: (E)-(3R,6R)-6-Benzyl-7-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-cyclohexylmethyl-7-oxo-hept-4-enoic acid ethyl ester
• CAS No.: 149228-51-3
• Molecular Formula: C₃₃H₄₁NO₅
• Molecular Weight: 531.692

Synonyms:(E)-(3R,6R)-6-Benzyl-7-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-cyclohexylmethyl-7-oxo-hept-4-enoic acid ethyl ester

Chemical Property of (E)-(3R,6R)-6-Benzyl-7-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-cyclohexylmethyl-7-oxo-hept-4-enoic acid ethyl ester

Chemical Property:

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Technology Process of (E)-(3R,6R)-6-Benzyl-7-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-cyclohexylmethyl-7-oxo-hept-4-enoic acid ethyl ester

There total 3 articles about (E)-(3R,6R)-6-Benzyl-7-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-cyclohexylmethyl-7-oxo-hept-4-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

Triethyl orthoacetate (78-39-7) → (E)-(3R,6R)-6-Benzyl-7-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-cyclohexylmethyl-7-oxo-hept-4-enoic acid ethyl ester (149228-51-3)

Guidance literature:

With Trimethylacetic acid; In toluene; Heating;

DOI:10.1016/S0040-4039(00)91945-2

Reference yield:

(E)-4-cyclohexyl-2-buten-1-al (4404-92-6) → (E)-(3R,6R)-6-Benzyl-7-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-cyclohexylmethyl-7-oxo-hept-4-enoic acid ethyl ester (149228-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) Bu₂BOTf, (i-Pr)2NEt

2: 81 percent / pivalic acid / toluene / Heating

With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; Trimethylacetic acid; In toluene;

DOI:10.1016/S0040-4039(00)91945-2

Reference yield:

(R)-4-benzyl-3-(3-phenyl-propionyl)-oxazolidin-2-one (136159-65-4) → (E)-(3R,6R)-6-Benzyl-7-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-cyclohexylmethyl-7-oxo-hept-4-enoic acid ethyl ester (149228-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) Bu₂BOTf, (i-Pr)2NEt

2: 81 percent / pivalic acid / toluene / Heating

With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; Trimethylacetic acid; In toluene;

DOI:10.1016/S0040-4039(00)91945-2

upstream raw materials:

Triethyl orthoacetate

(E)-4-cyclohexyl-2-buten-1-al

(R)-4-benzyl-3-(3-phenyl-propionyl)-oxazolidin-2-one

Downstream raw materials:

(E)-(2R,5R)-2-Benzyl-5-cyclohexylmethyl-hept-3-enedioic acid 7-ethyl ester

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