(+)-1-[(1S,2S,5R)-6-benzyl-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]non-8-yl]-2-(3,4-dichlorophenyl)ethanone

Base Information

Chemical Name:(+)-1-[(1S,2S,5R)-6-benzyl-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]non-8-yl]-2-(3,4-dichlorophenyl)ethanone
CAS No.:1228313-59-4
Molecular Formula:C₂₆H₃₁Cl₂N₃O
Molecular Weight:472.458
Hs Code.:

Synonyms:(+)-1-[(1S,2S,5R)-6-benzyl-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]non-8-yl]-2-(3,4-dichlorophenyl)ethanone

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Chemical Property of (+)-1-[(1S,2S,5R)-6-benzyl-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]non-8-yl]-2-(3,4-dichlorophenyl)ethanone

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Technology Process of (+)-1-[(1S,2S,5R)-6-benzyl-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]non-8-yl]-2-(3,4-dichlorophenyl)ethanone

There total 1 articles about (+)-1-[(1S,2S,5R)-6-benzyl-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]non-8-yl]-2-(3,4-dichlorophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1228313-55-0
(-)-(1S,2S,5R)-6-benzyl-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]nonane

: 6831-55-6
2-(3,4-dichlorophenyl)acetyl chloride

: 1228313-59-4
(+)-1-[(1S,2S,5R)-6-benzyl-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]non-8-yl]-2-(3,4-dichlorophenyl)ethanone

Guidance literature:: In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm100182p

Reference yield: 65.0%

: 1228313-59-4
(+)-1-[(1S,2S,5R)-6-benzyl-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]non-8-yl]-2-(3,4-dichlorophenyl)ethanone

: 1228313-62-9
1-[(1S,2S,5R)-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]non-8-yl]-2-(3,4-dichlorophenyl)ethanone

Guidance literature:: With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; water; at 20 ℃; for 0.5h;
DOI:10.1021/jm100182p