1,3-dimethoxy-2-{[2-(1-methylethenyl)phenyl]methoxy}benzene

Base Information

• Chemical Name: 1,3-dimethoxy-2-{[2-(1-methylethenyl)phenyl]methoxy}benzene
• CAS No.: 1323263-84-8
• Molecular Formula: C₁₈H₂₀O₃
• Molecular Weight: 284.355
• Mol file: 1323263-84-8.mol

Synonyms:1,3-dimethoxy-2-{[2-(1-methylethenyl)phenyl]methoxy}benzene

Chemical Property of 1,3-dimethoxy-2-{[2-(1-methylethenyl)phenyl]methoxy}benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-dimethoxy-2-{[2-(1-methylethenyl)phenyl]methoxy}benzene

There total 1 articles about 1,3-dimethoxy-2-{[2-(1-methylethenyl)phenyl]methoxy}benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1,3-dimethoxy-2-hydroxy-benzene (91-10-1) + [2-(1-methylethenyl)phenyl]methyl alcohol (180092-32-4) → 1,3-dimethoxy-2-{[2-(1-methylethenyl)phenyl]methoxy}benzene (1323263-84-8)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1135/cccc2011017

Reference yield: 100.0%

1,3-dimethoxy-2-{[2-(1-methylethenyl)phenyl]methoxy}benzene (1323263-84-8) → 2-{2-[(2,6-dimethoxyphenoxy)methyl]phenyl}propane-1,2-diol (1323263-93-9)

Guidance literature:

With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In water; acetone; at 20 ℃;

DOI:10.1135/cccc2011017

Reference yield:

1,3-dimethoxy-2-{[2-(1-methylethenyl)phenyl]methoxy}benzene (1323263-84-8) → 2-{2-[(2,6-dimethoxyphenoxy)methyl]phenyl}-2-hydroxypropanal (1323264-02-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone / 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 - 0 °C / Inert atmosphere

With osmium(VIII) oxide; oxalyl dichloride; dimethyl sulfoxide; 4-methylmorpholine N-oxide; In dichloromethane; water; acetone; 2.2: Swern oxidation;

DOI:10.1135/cccc2011017

upstream raw materials:

1,3-dimethoxy-2-hydroxy-benzene

[2-(1-methylethenyl)phenyl]methyl alcohol

Downstream raw materials:

2-{2-[(2,6-dimethoxyphenoxy)methyl]phenyl}propane-1,2-diol

2-{2-[(2,6-dimethoxyphenoxy)methyl]phenyl}-2-hydroxypropanal

2-{2-[(2,6-dimethoxyphenoxy)methyl]phenyl}-2-hydroxypropanoic acid

rac-N-{1-[(phenyl)methyl]piperidin-4-yl}-2-{2-[(2,6-dimethoxyphenoxy)methyl]phenyl}-2-hydroxypropanamide