C₆₆H₇₃Cl₃N₄O₁₆S

Base Information

• Chemical Name: C₆₆H₇₃Cl₃N₄O₁₆S
• CAS No.: 854022-04-1
• Molecular Formula: C₆₆H₇₃Cl₃N₄O₁₆S
• Molecular Weight: 1316.75
• Mol file: 854022-04-1.mol

Synonyms:C₆₆H₇₃Cl₃N₄O₁₆S

Chemical Property of C₆₆H₇₃Cl₃N₄O₁₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₆H₇₃Cl₃N₄O₁₆S

There total 27 articles about C₆₆H₇₃Cl₃N₄O₁₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(R)-N-Troc-S-tris(4-methoxyphenyl)methyl cystein + [(1S,2R)-2-((5R,7R,10R)-11-Allyloxy-7-hydroxymethyl-2,2,12-trimethyl-4,5,7,10-tetrahydro-1,3,15,17-tetraoxa-6-aza-cyclopenta[a]phenanthren-6-yl)-1-(3-allyloxy-4-methoxy-5-methyl-benzyl)-2-cyano-ethyl]-carbamic acid allyl ester (854021-99-1) → C66H73Cl3N4O16S (854022-04-1)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

DOI:10.1021/jo050408k

Reference yield:

2-(benzhydrylidene-amino)-3-[4-methoxy-3-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-propionic acid tert-butyl ester → C66H73Cl3N4O16S (854022-04-1)

Guidance literature:

Multi-step reaction with 9 steps

1: AcOH / tetrahydrofuran; H₂O / 2 h / 20 °C

2: LiBH₄ / diethyl ether; methanol / 20 °C

3: NaOH / ethanol; H₂O / 8 h / 80 °C

4: NaHCO₃ / H₂O; CH₂Cl₂ / 1 h / 20 °C

5: K₂CO₃ / acetone / 4 h / Heating

6: DMSO; oxalyl chloride; triethylamine / CH₂Cl₂ / 1.17 h / -78 - 0 °C

7: molecular sieves 3 Angstroem / toluene / 40 °C

8: 96.0 mg / BF₃*OEt₂ / CH₂Cl₂ / 1.5 h / -30 °C

9: 73 percent / DMAP; EDCl / CH₂Cl₂ / 20 °C

With dmap; sodium hydroxide; lithium borohydride; oxalyl dichloride; 3 A molecular sieve; boron trifluoride diethyl etherate; sodium hydrogencarbonate; potassium carbonate; acetic acid; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; acetone; toluene; 6: Swern oxidation;

DOI:10.1021/jo050408k

Reference yield:

(5R,7R,10R)-11-Allyloxy-2,2,12-trimethyl-4,5,7,10-tetrahydro-1,3,15,17-tetraoxa-6-aza-cyclopenta[a]phenanthrene-6,7-dicarboxylic acid 7-ethyl ester 6-(2,2,2-trichloro-ethyl) ester → C66H73Cl3N4O16S (854022-04-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 205.0 mg / Zn; AcOH / diethyl ether / 1 h / 20 °C

2: 90 percent / LiAlH₄ / tetrahydrofuran / 2.5 h / -20 - 0 °C

3: molecular sieves 3 Angstroem / toluene / 40 °C

4: 96.0 mg / BF₃*OEt₂ / CH₂Cl₂ / 1.5 h / -30 °C

5: 73 percent / DMAP; EDCl / CH₂Cl₂ / 20 °C

With dmap; lithium aluminium tetrahydride; 3 A molecular sieve; boron trifluoride diethyl etherate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;

DOI:10.1021/jo050408k

upstream raw materials:

[(1S,2R)-2-((5R,7R,10R)-11-Allyloxy-7-hydroxymethyl-2,2,12-trimethyl-4,5,7,10-tetrahydro-1,3,15,17-tetraoxa-6-aza-cyclopenta[a]phenanthren-6-yl)-1-(3-allyloxy-4-methoxy-5-methyl-benzyl)-2-cyano-ethyl]-carbamic acid allyl ester

5-methoxy methoxy-4-methyl benzo[d][1,3]dioxole

4-methylbenzo[1,3]dioxol-5-ol

3-methylbenzene-1,2-diol