5-Amino-2-benzylbenzo[de]isoquinoline-1,3-dione

Base Information

• Chemical Name: 5-Amino-2-benzylbenzo[de]isoquinoline-1,3-dione
• CAS No.: 24782-10-3
• Molecular Formula: C₁₉H₁₄N₂O₂
• Molecular Weight: 302.332
• NSC Number: 201947
• DSSTox Substance ID: DTXSID00308078
• Wikidata: Q82055752
• Mol file: 24782-10-3.mol

Synonyms:24782-10-3;5-amino-2-benzylbenzo[de]isoquinoline-1,3-dione;NSC201947;DTXSID00308078;NSC-201947;5-amino-2-benzyl-1h-benzo[de]isoquinoline-1,3(2h)-dione

Chemical Property of 5-Amino-2-benzylbenzo[de]isoquinoline-1,3-dione

Chemical Property:

• Vapor Pressure: 8.43E-13mmHg at 25°C
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 302.105527694
• Heavy Atom Count: 23
• Complexity: 486

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CN2C(=O)C3=CC=CC4=CC(=CC(=C43)C2=O)N

Technology Process of 5-Amino-2-benzylbenzo[de]isoquinoline-1,3-dione

There total 3 articles about 5-Amino-2-benzylbenzo[de]isoquinoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-benzyl-5-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione → 3-amino-N-(benzyl)-1,8-naphthalimide (24782-10-3)

Guidance literature:

With palladium 10% on activated carbon; hydrazine; In ethanol; at 60 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.saa.2020.118442

Reference yield:

3-nitro-1,8-naphthalic anhydride (3027-38-1) → 3-amino-N-(benzyl)-1,8-naphthalimide (24782-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 2 h / 90 °C / Sealed tube

2: hydrazine; palladium 10% on activated carbon / ethanol / 6 h / 60 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrazine; In ethanol;

DOI:10.1016/j.saa.2020.118442

Reference yield:

benzylamine (100-46-9) → 3-amino-N-(benzyl)-1,8-naphthalimide (24782-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 2 h / 90 °C / Sealed tube

2: hydrazine; palladium 10% on activated carbon / ethanol / 6 h / 60 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrazine; In ethanol;

DOI:10.1016/j.saa.2020.118442

upstream raw materials:

3-nitro-1,8-naphthalic anhydride

benzylamine

Refernces