ethyl {4-[(butyl{6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl}amino)methyl]-2-methylphenoxy}acetate

Base Information

Chemical Name:ethyl {4-[(butyl{6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl}amino)methyl]-2-methylphenoxy}acetate
CAS No.:637352-88-6
Molecular Formula:C₂₇H₃₀F₃N₃O₃
Molecular Weight:501.549
Hs Code.:

Synonyms:ethyl {4-[(butyl{6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl}amino)methyl]-2-methylphenoxy}acetate

Suppliers and Price of ethyl {4-[(butyl{6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl}amino)methyl]-2-methylphenoxy}acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl {4-[(butyl{6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl}amino)methyl]-2-methylphenoxy}acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl {4-[(butyl{6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl}amino)methyl]-2-methylphenoxy}acetate

There total 5 articles about ethyl {4-[(butyl{6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl}amino)methyl]-2-methylphenoxy}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 637352-86-4
2-bromo-6-[4-(trifluoromethyl)phenyl]pyrazine

: 637352-47-7
ethyl {4-[(butylamino)methyl]-2-methylphenoxy}acetate

: 637352-88-6
ethyl {4-[(butyl{6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl}amino)methyl]-2-methylphenoxy}acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; at 100 ℃; for 18h;

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 637352-88-6
ethyl {4-[(butyl{6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl}amino)methyl]-2-methylphenoxy}acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / 20 °C / Heating / reflux

2: phosphorus tribromide / 6 h / Heating / reflux

3: N-ethyl-N,N-diisopropylamine / 18 h / 100 °C

With phosphorus tribromide; sodium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water;

Reference yield:

: 637352-46-6
ethyl (4-formyl-2-methylphenoxy)acetate

: 637352-88-6
ethyl {4-[(butyl{6-[4-(trifluoromethyl)phenyl]pyrazin-2-yl}amino)methyl]-2-methylphenoxy}acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4 A molecular sieve / ethanol / 18 h / 20 °C

1.2: 3 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / 18 h / 100 °C

With 4 A molecular sieve; N-ethyl-N,N-diisopropylamine; In ethanol;