(2S,4R)-5-(3'-chlorobiphenyl-4-yl)-2-methoxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid

Base Information

Chemical Name:(2S,4R)-5-(3'-chlorobiphenyl-4-yl)-2-methoxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid
CAS No.:1562404-31-2
Molecular Formula:C₂₃H₂₅ClN₄O₄
Molecular Weight:456.929
Hs Code.:

Synonyms:(2S,4R)-5-(3'-chlorobiphenyl-4-yl)-2-methoxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid

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Chemical Property of (2S,4R)-5-(3'-chlorobiphenyl-4-yl)-2-methoxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid

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Technology Process of (2S,4R)-5-(3'-chlorobiphenyl-4-yl)-2-methoxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid

There total 11 articles about (2S,4R)-5-(3'-chlorobiphenyl-4-yl)-2-methoxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3H-[1,2,3]triazole-4-carboxylic acid

: 1562404-90-3
(2S,4R)-4-amino-5-(3'-chlorobiphenyl-4-yl)-2-methoxymethyl-2-methylpentanoic acid ethyl ester

: 1562404-31-2
(2S,4R)-5-(3'-chlorobiphenyl-4-yl)-2-methoxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid

Guidance literature:: 3H-[1,2,3]triazole-4-carboxylic acid; With HATU; In N,N-dimethyl-formamide; for 0.0833333h;

(2S,4R)-4-amino-5-(3'-chlorobiphenyl-4-yl)-2-methoxymethyl-2-methylpentanoic acid ethyl ester; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.333333h;

With sodium hydroxide; In tetrahydrofuran; at 60 ℃; for 2h;

Reference yield:

: 1562404-89-0
(2S,4R)-4-t-butoxycarbonylamino-5-(3‘-chlorobiphenyl-4-yl)-2-hydroxymethyl-2-methylpentanoic acid ethyl ester

: 1562404-31-2
(2S,4R)-5-(3'-chlorobiphenyl-4-yl)-2-methoxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / Sealed tube

2.1: hydrogenchloride / 1,4-dioxane; acetonitrile / 0.17 h

3.1: HATU / N,N-dimethyl-formamide / 0.08 h

3.2: 0.33 h

3.3: 2 h / 60 °C

With hydrogenchloride; tetra(n-butyl)ammonium hydrogensulfate; HATU; sodium hydroxide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1383027-95-9
C₂₀H₂₄BrNO₇

: 1562404-31-2
(2S,4R)-5-(3'-chlorobiphenyl-4-yl)-2-methoxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere

1.2: 3.5 h / -5 - 23 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 23 °C

3.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium fluoride / water; 1,4-dioxane / 3 h / 60 °C / Inert atmosphere

4.1: water; samarium; iodine / tetrahydrofuran / 2 h / -70 - 23 °C / Inert atmosphere; Sealed tube

5.1: hydrogenchloride / 1,4-dioxane / 3 h / 60 °C

6.1: triethylamine; dmap / dichloromethane / 3 h

7.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / Sealed tube

8.1: hydrogenchloride / 1,4-dioxane; acetonitrile / 0.17 h

9.1: HATU / N,N-dimethyl-formamide / 0.08 h

9.2: 0.33 h

9.3: 2 h / 60 °C

With hydrogenchloride; dmap; potassium fluoride; samarium; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; water; iodine; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; acetic acid; triethylamine; HATU; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;