1-(3-{[5-Methyl-3-(3-{4-[(trifluoromethyl)sulphanyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}phenyl)piperidin-4-ol

Base Information

Chemical Name:1-(3-{[5-Methyl-3-(3-{4-[(trifluoromethyl)sulphanyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}phenyl)piperidin-4-ol
CAS No.:1347581-55-8
Molecular Formula:C₂₅H₂₄F₃N₅O₂S
Molecular Weight:515.559
Hs Code.:

Synonyms:1-(3-{[5-Methyl-3-(3-{4-[(trifluoromethyl)sulphanyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}phenyl)piperidin-4-ol

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Chemical Property of 1-(3-{[5-Methyl-3-(3-{4-[(trifluoromethyl)sulphanyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}phenyl)piperidin-4-ol

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Technology Process of 1-(3-{[5-Methyl-3-(3-{4-[(trifluoromethyl)sulphanyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}phenyl)piperidin-4-ol

There total 5 articles about 1-(3-{[5-Methyl-3-(3-{4-[(trifluoromethyl)sulphanyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}phenyl)piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₁H₄₂F₃N₅O₂SSi

: 1347581-55-8
1-(3-{[5-Methyl-3-(3-{4-[(trifluoromethyl)sulphanyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}phenyl)piperidin-4-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.333333h;

Reference yield:

: 1085453-81-1
N'-hydroxy-4-[(trifluoromethyl)sulphanyl]benzenecarboximidamide

: 1347581-55-8
1-(3-{[5-Methyl-3-(3-{4-[(trifluoromethyl)sulphanyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}phenyl)piperidin-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 4 h / 110 °C

2.1: potassium tert-butylate / 1,4-dioxane / 16 h / 20 °C

3.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / toluene / 3 h / 80 °C / Inert atmosphere; Microwave irradiation

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 20 °C

With potassium tert-butylate; tetrabutyl ammonium fluoride; 1,1'-carbonyldiimidazole; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1347581-78-5
5-[1-(3-Bromobenzyl)-5-methyl-1H-pyrazol-3-yl]-3-{4-[(trifluoromethyl)sulphanyl]phenyl}-1,2,4-oxadiazole

: 1347581-55-8
1-(3-{[5-Methyl-3-(3-{4-[(trifluoromethyl)sulphanyl]phenyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]methyl}phenyl)piperidin-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / toluene / 3 h / 80 °C / Inert atmosphere; Microwave irradiation

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 20 °C

With tetrabutyl ammonium fluoride; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; toluene;