(3S)-4-[[(4S)-4-(4-chloro-3-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid

Base Information

• Chemical Name: (3S)-4-[[(4S)-4-(4-chloro-3-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
• CAS No.: 1578154-74-1
• Molecular Formula: C₂₁H₂₀ClFN₄O₅S
• Molecular Weight: 494.931
• Mol file: 1578154-74-1.mol

Synonyms:(3S)-4-[[(4S)-4-(4-chloro-3-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid

Chemical Property of (3S)-4-[[(4S)-4-(4-chloro-3-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S)-4-[[(4S)-4-(4-chloro-3-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid

There total 5 articles about (3S)-4-[[(4S)-4-(4-chloro-3-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

(3S)-morpholine-3-carboxylic acid hydrochloride salt (1187929-04-9,66937-99-3) + methyl (4S)-6-(bromomethyl)-4-(4-chloro-3-fluorophenyl)-2-thiazol-2-yl-1,4-dihydropyrimidine-5-carboxylate → (3S)-4-[[(4S)-4-(4-chloro-3-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid (1578154-74-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.jmedchem.9b01421

Reference yield:

4-chloro-3-fluorobenzaldehyde (5527-95-7) → (3S)-4-[[(4S)-4-(4-chloro-3-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid (1578154-74-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: acetic acid; piperidine / isopropyl alcohol / 2 h / 48 °C

1.2: 3 h / 90 °C

2.1: Daicel Chiralpak IC / Resolution of racemate; Supercritical conditions

3.1: N-Bromosuccinimide / tetrachloromethane

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With piperidine; N-Bromosuccinimide; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrachloromethane; dichloromethane; isopropyl alcohol;

DOI:10.1021/acs.jmedchem.9b01421

Reference yield:

4-(4-chloro-3-fluoro-phenyl)-6-methyl-2-thiazol-2-yl-1,4-dihydropyrimidine-5-carboxylic acid methyl ester → (3S)-4-[[(4S)-4-(4-chloro-3-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid (1578154-74-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Daicel Chiralpak IC / Resolution of racemate; Supercritical conditions

2: N-Bromosuccinimide / tetrachloromethane

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With N-Bromosuccinimide; N-ethyl-N,N-diisopropylamine; In tetrachloromethane; dichloromethane;

DOI:10.1021/acs.jmedchem.9b01421

upstream raw materials:

4-chloro-3-fluorobenzaldehyde

(3S)-morpholine-3-carboxylic acid hydrochloride salt