2',3'-dideoxy-N⁶,N⁶-dimethyl-3'-(4-O-methyl-L-tyrosylamido)adenosine

Base Information

• Chemical Name: 2',3'-dideoxy-N⁶,N⁶-dimethyl-3'-(4-O-methyl-L-tyrosylamido)adenosine
• CAS No.: 132370-60-6
• Molecular Formula: C₂₂H₂₉N₇O₄
• Molecular Weight: 455.517
• Mol file: 132370-60-6.mol

Synonyms:2',3'-dideoxy-N⁶,N⁶-dimethyl-3'-(4-O-methyl-L-tyrosylamido)adenosine

Chemical Property of 2',3'-dideoxy-N⁶,N⁶-dimethyl-3'-(4-O-methyl-L-tyrosylamido)adenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2',3'-dideoxy-N⁶,N⁶-dimethyl-3'-(4-O-methyl-L-tyrosylamido)adenosine

There total 14 articles about 2',3'-dideoxy-N⁶,N⁶-dimethyl-3'-(4-O-methyl-L-tyrosylamido)adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2',3'-dideoxy-N6,N6-dimethyl-3'-(Nα-Fmoc-4-O-methyl-L-tyrosylamido)adenosine → 2',3'-dideoxy-N6,N6-dimethyl-3'-(4-O-methyl-L-tyrosylamido)adenosine (132370-60-6)

Guidance literature:

With morpholine; In N,N-dimethyl-formamide; for 0.333333h; Ambient temperature;

DOI:10.1055/s-1995-3892

Reference yield: 63.0%

6-dimethylamino-9-<3'-(benzyloxycarbonyl-p-methoxyphenyl-L-alanylamino)-2',3'-dideoxy-β-D-ribofuranosyl>purine (132370-68-4) → 2',3'-dideoxy-N6,N6-dimethyl-3'-(4-O-methyl-L-tyrosylamido)adenosine (132370-60-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; ethanol; for 18h; Ambient temperature;

DOI:10.1080/00021369.1990.10870451

Reference yield:

(2S)-2-[(benzyloxycarbonyl)amino]-3-(4-methoxyphenyl)propanoic acid (17554-34-6) → 2',3'-dideoxy-N6,N6-dimethyl-3'-(4-O-methyl-L-tyrosylamido)adenosine (132370-60-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) PPh₃ / 1) toluene, r.t., 2h, 2) reflux, 20h

2: 63 percent / H₂ / 10percent Pd/C / dioxane; ethanol / 18 h / Ambient temperature

With hydrogen; triphenylphosphine; palladium on activated charcoal; In 1,4-dioxane; ethanol;

DOI:10.1080/00021369.1990.10870451

upstream raw materials:

6-dimethylamino-9-<3'-(benzyloxycarbonyl-p-methoxyphenyl-L-alanylamino)-2',3'-dideoxy-β-D-ribofuranosyl>purine

(2S)-2-[(benzyloxycarbonyl)amino]-3-(4-methoxyphenyl)propanoic acid

6-dimethylamino-9-(2'-deoxy-β-D-xylofuranosyl)purine

6-dimethylamino-9-(3'-azido-2',3'-dideoxy-3'-β-D-ribofuranosyl)purine