(S)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)-1-(1-(5-isopropylpyrimidin-2-yl)piperidin-4-yl)pyrrolidin-2-one trifluoroacetate

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Chemical Name:(S)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)-1-(1-(5-isopropylpyrimidin-2-yl)piperidin-4-yl)pyrrolidin-2-one trifluoroacetate
CAS No.:1351166-41-0
Molecular Formula:C₂HF₃O₂*C₂₃H₃₀FN₅O₃S
Molecular Weight:589.611
Hs Code.:

Synonyms:(S)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)-1-(1-(5-isopropylpyrimidin-2-yl)piperidin-4-yl)pyrrolidin-2-one trifluoroacetate

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Chemical Property of (S)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)-1-(1-(5-isopropylpyrimidin-2-yl)piperidin-4-yl)pyrrolidin-2-one trifluoroacetate

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Technology Process of (S)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)-1-(1-(5-isopropylpyrimidin-2-yl)piperidin-4-yl)pyrrolidin-2-one trifluoroacetate

There total 1 articles about (S)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)-1-(1-(5-isopropylpyrimidin-2-yl)piperidin-4-yl)pyrrolidin-2-one trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.7%

: 1351166-16-9
(S)-1-(1-(5-bromopyrimidin-2-yl)piperidin-4-yl)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)pyrrolidin-2-one

: 625-81-0
diisopropyl zinc

: 76-05-1
trifluoroacetic acid

: 1351166-41-0
(S)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)-1-(1-(5-isopropylpyrimidin-2-yl)piperidin-4-yl)pyrrolidin-2-one trifluoroacetate

Guidance literature:: (S)-1-(1-(5-bromopyrimidin-2-yl)piperidin-4-yl)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)pyrrolidin-2-one; diisopropyl zinc; With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; at 100 ℃; for 3h; Inert atmosphere;

trifluoroacetic acid; In water; acetonitrile;