ethyl ((1S)-5-{3-[4-(aminocarbonothioyl)-2-methoxyphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl)acetic acid

Base Information

Chemical Name:ethyl ((1S)-5-{3-[4-(aminocarbonothioyl)-2-methoxyphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl)acetic acid
CAS No.:724467-26-9
Molecular Formula:C₂₄H₂₉NO₅S
Molecular Weight:443.564
Hs Code.:

Synonyms:ethyl ((1S)-5-{3-[4-(aminocarbonothioyl)-2-methoxyphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl)acetic acid

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Chemical Property of ethyl ((1S)-5-{3-[4-(aminocarbonothioyl)-2-methoxyphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl)acetic acid

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Technology Process of ethyl ((1S)-5-{3-[4-(aminocarbonothioyl)-2-methoxyphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl)acetic acid

There total 8 articles about ethyl ((1S)-5-{3-[4-(aminocarbonothioyl)-2-methoxyphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 724467-25-8
{5-[3-(4-cyano-2-methoxy-phenoxy)-propoxy]-indan-1-yl}-acetic acid ethyl ester

: 724467-26-9
ethyl ((1S)-5-{3-[4-(aminocarbonothioyl)-2-methoxyphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl)acetic acid

Guidance literature:: With hydrogen sulfide; diethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 3h;
DOI:10.1021/jm061299k

Reference yield:

: 5111-70-6
5-methoxy-1-indanone

: 724467-26-9
ethyl ((1S)-5-{3-[4-(aminocarbonothioyl)-2-methoxyphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1: Zn / CuCl / tetrahydrofuran / 16 h / 20 - 35 °C

2: H₂ / Pd/C / ethanol / 2068.59 Torr

3: 146.9 g / Amano Lipase PS / aq. phosphate buffer / 12 h / 20 °C / pH 7.0

4: 100 percent / chlorotrimethylsilane / 12 h / 20 °C

5: 96 percent / AlCl₃; EtSH / CH₂Cl₂ / 2.5 h / 10 °C

6: Cs₂CO₃ / dimethylformamide / 14 h / 20 - 80 °C

7: Cs₂CO₃ / dimethylformamide; H₂O / 16 h / 40 °C

8: 81 percent / H₂S; Et₂NH / dimethylformamide / 3 h / 60 °C

With chloro-trimethyl-silane; aluminium trichloride; Amano Lipase PS; hydrogen sulfide; hydrogen; caesium carbonate; diethylamine; ethanethiol; zinc; palladium on activated charcoal; copper(l) chloride; In tetrahydrofuran; phosphate buffer; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Reformatsky reaction;
DOI:10.1021/jm061299k

Reference yield:

: 21779-34-0
ethyl 2-[(1E)-5-methoxy-2,3-dihydro-1H-inden-1-ylidene]acetate

: 724467-26-9
ethyl ((1S)-5-{3-[4-(aminocarbonothioyl)-2-methoxyphenoxy]propoxy}-2,3-dihydro-1H-inden-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / Pd/C / ethanol / 2068.59 Torr

2: 146.9 g / Amano Lipase PS / aq. phosphate buffer / 12 h / 20 °C / pH 7.0

3: 100 percent / chlorotrimethylsilane / 12 h / 20 °C

4: 96 percent / AlCl₃; EtSH / CH₂Cl₂ / 2.5 h / 10 °C

5: Cs₂CO₃ / dimethylformamide / 14 h / 20 - 80 °C

6: Cs₂CO₃ / dimethylformamide; H₂O / 16 h / 40 °C

7: 81 percent / H₂S; Et₂NH / dimethylformamide / 3 h / 60 °C

With chloro-trimethyl-silane; aluminium trichloride; Amano Lipase PS; hydrogen sulfide; hydrogen; caesium carbonate; diethylamine; ethanethiol; palladium on activated charcoal; In phosphate buffer; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm061299k