Technology Process of methyl 4-cyano-6-(N,N-diethylamino)-4-phenylhexanoate
There total 6 articles about methyl 4-cyano-6-(N,N-diethylamino)-4-phenylhexanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium cyanoborohydride;
In
methanol;
at 25 ℃;
for 0.25h;
Yield given;
DOI:10.1002/jhet.5570340250
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) NaH, DMSO / 1.) 55 deg C, 1 h, 2.) 55 deg C, 10 min
2: 1.) Triton B / 1.) THF, 25 deg C, 10 min, 2.) THF, 50 deg C, 30 min
3: 68 percent / 50percent aq. TFA / CH2Cl2 / 67 h / Ambient temperature
4: 164 Angstroem molecular sieves / methanol / 25 °C
5: NaBH3CN / methanol / 0.25 h / 25 °C
With
molecular sieve; N-benzyl-trimethylammonium hydroxide; sodium hydride; sodium cyanoborohydride; dimethyl sulfoxide; trifluoroacetic acid;
In
methanol; dichloromethane;
DOI:10.1002/jhet.5570340250
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) Triton B / 1.) THF, 25 deg C, 10 min, 2.) THF, 50 deg C, 30 min
2: 68 percent / 50percent aq. TFA / CH2Cl2 / 67 h / Ambient temperature
3: 164 Angstroem molecular sieves / methanol / 25 °C
4: NaBH3CN / methanol / 0.25 h / 25 °C
With
molecular sieve; N-benzyl-trimethylammonium hydroxide; sodium cyanoborohydride; trifluoroacetic acid;
In
methanol; dichloromethane;
DOI:10.1002/jhet.5570340250
