α,α-bis(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol

Base Information

• Chemical Name: α,α-bis(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol
• CAS No.: 99931-63-2
• Molecular Formula: C₂₄H₂₅F₃N₄O
• Molecular Weight: 442.484
• Mol file: 99931-63-2.mol

Synonyms:α,α-bis(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol

Chemical Property of α,α-bis(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α,α-bis(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol

There total 5 articles about α,α-bis(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-<5-fluoro-4-(methylthio)-2-pyrimidinyl>-1-piperazinecarboxylate (87789-50-2) → α,α-bis(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol (99931-63-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 45 percent / ethanol / Raney nickel / 48 h / Heating

2: 100 percent / 6N aq. HCl / Heating

3: K₂CO₃, KI / acetonitrile / 36 h / Heating

4: tetrahydrofuran / 18 h / Heating

With hydrogenchloride; ethanol; potassium carbonate; potassium iodide; nickel; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm00102a002

Reference yield:

5-fluoro-2-(piperazin-1-yl)-pyrimidine (87789-49-9) → α,α-bis(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol (99931-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃, KI / acetonitrile / 36 h / Heating

2: tetrahydrofuran / 18 h / Heating

With potassium carbonate; potassium iodide; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm00102a002

Reference yield:

ethyl 4-(5-fluoro-2-pyrimidinyl)-1-piperazinecarboxylate (87789-52-4) → α,α-bis(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol (99931-63-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / 6N aq. HCl / Heating

2: K₂CO₃, KI / acetonitrile / 36 h / Heating

3: tetrahydrofuran / 18 h / Heating

With hydrogenchloride; potassium carbonate; potassium iodide; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm00102a002

upstream raw materials:

5-fluoro-2-(piperazin-1-yl)-pyrimidine

ethyl 4-(5-fluoro-2-pyrimidinyl)-1-piperazinecarboxylate

ethyl 4-<5-fluoro-4-(methylthio)-2-pyrimidinyl>-1-piperazinecarboxylate

4-(4-fluorophenyl)-4-oxo-n-butyl chloride