(2R,3R)-3-((tert-butyldimethylsilyl)oxy)-2',3'-dimethoxy-2,3,4,5-tetrahydro-[1,1'-biphenyl]-2-ol

Base Information

• Chemical Name: (2R,3R)-3-((tert-butyldimethylsilyl)oxy)-2',3'-dimethoxy-2,3,4,5-tetrahydro-[1,1'-biphenyl]-2-ol
• CAS No.: 1005000-01-0
• Molecular Formula: C₂₀H₃₂O₄Si
• Molecular Weight: 364.557

Synonyms:(2R,3R)-3-((tert-butyldimethylsilyl)oxy)-2',3'-dimethoxy-2,3,4,5-tetrahydro-[1,1'-biphenyl]-2-ol

Chemical Property of (2R,3R)-3-((tert-butyldimethylsilyl)oxy)-2',3'-dimethoxy-2,3,4,5-tetrahydro-[1,1'-biphenyl]-2-ol

Chemical Property:

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Technology Process of (2R,3R)-3-((tert-butyldimethylsilyl)oxy)-2',3'-dimethoxy-2,3,4,5-tetrahydro-[1,1'-biphenyl]-2-ol

There total 1 articles about (2R,3R)-3-((tert-butyldimethylsilyl)oxy)-2',3'-dimethoxy-2,3,4,5-tetrahydro-[1,1'-biphenyl]-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

tert-butyl(((2R,3R)-2',3'-dimethoxy-2-((4-methoxybenzyl)oxy)-2,3,4,5-tetrahydro-[1,1'-biphenyl]-3-yl)oxy)dimethylsilane (1005000-00-9) → (2R,3R)-3-((tert-butyldimethylsilyl)oxy)-2',3'-dimethoxy-2,3,4,5-tetrahydro-[1,1'-biphenyl]-2-ol (1005000-01-0)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; at 0 - 20 ℃; for 0.75h; Inert atmosphere;

DOI:10.1002/chem.201203284

Reference yield: 100.0%

(2R,3R)-3-((tert-butyldimethylsilyl)oxy)-2',3'-dimethoxy-2,3,4,5-tetrahydro-[1,1'-biphenyl]-2-ol (1005000-01-0) → (2R,3R)-2',3'-dimethoxy-2,3,4,5-tetrahydro-[1,1'-biphenyl]-2,3-diol (1004999-94-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2007.11.037

Reference yield: 87.0%

(2R,3R)-3-((tert-butyldimethylsilyl)oxy)-2',3'-dimethoxy-2,3,4,5-tetrahydro-[1,1'-biphenyl]-2-ol (1005000-01-0) + Triethyl orthoacetate (78-39-7) → ethyl 2-((2S,5R)-5-((tert-butyldimethylsilyl)oxy)-2',3'-dimethoxy-2,3,4,5-tetrahydro-[1,1'-biphenyl]-2-yl)acetate (1005000-02-1)

Guidance literature:

With propionic acid; at 140 ℃; for 24h;

DOI:10.1016/j.tetlet.2007.11.037

upstream raw materials:

tert-butyl(((2R,3R)-2',3'-dimethoxy-2-((4-methoxybenzyl)oxy)-2,3,4,5-tetrahydro-[1,1'-biphenyl]-3-yl)oxy)dimethylsilane

Downstream raw materials:

(2R,3R)-2',3'-dimethoxy-2,3,4,5-tetrahydro-[1,1'-biphenyl]-2,3-diol

ethyl 2-((2S,5R)-5-((tert-butyldimethylsilyl)oxy)-2',3'-dimethoxy-2,3,4,5-tetrahydro-[1,1'-biphenyl]-2-yl)acetate

N-(2-((3R,3aR,3a1S,9aS)-3-hydroxy-5-methoxy-1,2,3,3a,3a1,9a-hexahydrophenanthro[4,5-bcd]furan-3a1-yl)ethyl)-N,4-dimethylbenzenesulfonamide

N-(2-(3-hydroxy-5-methoxy-3,3a,3a¹,9a-tetrahydrophenanthro[4,5-bcd]furan-3a¹-yl)ethyl)-N,4-dimethylbenzenesulfonamide

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