(S)-3-Methylpyrrolidine

Base Information

Chemical Name:(S)-3-Methylpyrrolidine
CAS No.:69498-25-5
Molecular Formula:C₅H₁₁N
Molecular Weight:85.149
Hs Code.:
DSSTox Substance ID:DTXSID10348925
Nikkaji Number:J785.184G
Wikidata:Q72497118
Mol file:69498-25-5.mol

Synonyms:(3S)-3-methylpyrrolidine;69498-25-5;(S)-3-METHYLPYRROLIDINE;Pyrrolidine, 3-methyl-,(3S)-;Pyrrolidine, 3-methyl-, (S)-;3beta-Methylpyrrolidine;DTXSID10348925;AKOS024258798;CS-0183104;EN300-2966777

Suppliers and Price of (S)-3-Methylpyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(3S)-3-Methylpyrrolidine
50mg
$ 75.00

American Custom Chemicals Corporation
(S)-3-METHYL-PYRROLIDINE 95.00%
5MG
$ 499.58

Total 9 raw suppliers

Chemical Property of (S)-3-Methylpyrrolidine

Chemical Property:

Vapor Pressure:37.1mmHg at 25°C
Boiling Point:100 ºC
Flash Point:0.5°C
PSA：12.03000
Density:0.812
LogP:0.94460
XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:85.089149355
Heavy Atom Count:6
Complexity:43.2

Purity/Quality:

97% ^*data from raw suppliers

(3S)-3-Methylpyrrolidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CCNC1
Isomeric SMILES:C[C@H]1CCNC1
Uses (3S)-3-Methylpyrrolidine is used as a reactant in the preparation of benzazepineylidene acetamide derivatives as arginine vasopressin V2 receptor agonists.

Technology Process of (S)-3-Methylpyrrolidine

There total 5 articles about (S)-3-Methylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-((S)-3-Methyl-pyrrolidin-1-yl)-2-phenyl-ethanol

: 69498-25-5
(S)-3-methyl pyrrolidine

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; acetic acid; for 24h; under 2280 Torr; Yield given;
DOI:10.1016/S0040-4039(00)79942-4

Reference yield:

: 155627-27-3
(3S,6S,7aR)-6-Methyl-3-phenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

: 69498-25-5
(S)-3-methyl pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

2: hydrogen / 10percent Pd/C / acetic acid; tetrahydrofuran / 24 h / 2280 Torr

With lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; acetic acid;
DOI:10.1016/S0040-4039(00)79942-4

Reference yield:

: 235094-13-0
1-((2S,4aS,7R,8aR)-4,4,7-Trimethyl-2-phenylselanylmethyl-hexahydro-benzo[e][1,3]oxazin-3-yl)-propenone

: 69498-25-5
(S)-3-methyl pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: tri-n-butyltin hydride, AIBN / benzene / Heating

2: aluminium hydride / tetrahydrofuran / -10 °C

3: 1.) PCC, 4 A mol. sieves, 2.) KOH / 2.) water, THF, MeOH

With aluminium hydride; potassium hydroxide; 2,2'-azobis(isobutyronitrile); 4 A molecular sieve; tri-n-butyl-tin hydride; pyridinium chlorochromate; In tetrahydrofuran; benzene;
DOI:10.1016/S0040-4039(96)02091-6