N-[4-({[7-cyano-2-(dimethylamino)quinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride

Base Information

Chemical Name:N-[4-({[7-cyano-2-(dimethylamino)quinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride
CAS No.:1039733-05-5
Molecular Formula:C₂₅H₂₁FN₆O*ClH
Molecular Weight:476.941
Hs Code.:

Synonyms:N-[4-({[7-cyano-2-(dimethylamino)quinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride

Suppliers and Price of N-[4-({[7-cyano-2-(dimethylamino)quinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[4-({[7-cyano-2-(dimethylamino)quinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[4-({[7-cyano-2-(dimethylamino)quinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride

There total 7 articles about N-[4-({[7-cyano-2-(dimethylamino)quinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1039733-00-0
N-[4-({[2-(dimethylamino)-7-iodoquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide

: 557-21-1
dicyanozinc

: 1039733-05-5
N-[4-({[7-cyano-2-(dimethylamino)quinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride

Guidance literature:: N-[4-({[2-(dimethylamino)-7-iodoquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide; dicyanozinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 5h;

With hydrogenchloride;

Reference yield:

: 959237-34-4
2,4-dichloro-7-iodoquinazoline

: 1039733-05-5
N-[4-({[7-cyano-2-(dimethylamino)quinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 h / 20 °C

2: tetrahydrofuran; water / 26 h / 100 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 5 h / 80 °C

With triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 959236-72-7
7-iodoquinazoline-2,4(1H,3H)-dione

: 1039733-05-5
N-[4-({[7-cyano-2-(dimethylamino)quinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / N,N-dimethyl-aniline / 6 h / 115 °C

1.2: pH 5 - 7

2.1: triethylamine / dichloromethane / 20 h / 20 °C

3.1: tetrahydrofuran; water / 26 h / 100 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 5 h / 80 °C

With triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-aniline; N,N-dimethyl-formamide;