8-α-vinyl-13-α-{4-[2-(2-oxy-3-phenylsulfonyl-1,2,5-oxadiazol-4-oxy)butynoxy]-succinyl}-oximethylene-isosteviol

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Chemical Name:8-α-vinyl-13-α-{4-[2-(2-oxy-3-phenylsulfonyl-1,2,5-oxadiazol-4-oxy)butynoxy]-succinyl}-oximethylene-isosteviol
CAS No.:1606163-21-6
Molecular Formula:C₃₇H₄₆N₂O₁₁S
Molecular Weight:726.845
Hs Code.:

Synonyms:8-α-vinyl-13-α-{4-[2-(2-oxy-3-phenylsulfonyl-1,2,5-oxadiazol-4-oxy)butynoxy]-succinyl}-oximethylene-isosteviol

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Chemical Property of 8-α-vinyl-13-α-{4-[2-(2-oxy-3-phenylsulfonyl-1,2,5-oxadiazol-4-oxy)butynoxy]-succinyl}-oximethylene-isosteviol

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Technology Process of 8-α-vinyl-13-α-{4-[2-(2-oxy-3-phenylsulfonyl-1,2,5-oxadiazol-4-oxy)butynoxy]-succinyl}-oximethylene-isosteviol

There total 3 articles about 8-α-vinyl-13-α-{4-[2-(2-oxy-3-phenylsulfonyl-1,2,5-oxadiazol-4-oxy)butynoxy]-succinyl}-oximethylene-isosteviol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 452095-56-6
4-((4-hydroxybut-2-yn-1-yl)oxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

: 1606163-09-0
8-α-vinyl-13-α-[(3-carboxyl acid-1-oxo-propoxy)-methylene]-isosteviol

: 1606163-21-6
8-α-vinyl-13-α-{4-[2-(2-oxy-3-phenylsulfonyl-1,2,5-oxadiazol-4-oxy)butynoxy]-succinyl}-oximethylene-isosteviol

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1016/j.bmcl.2014.03.004

Reference yield:

: 1606163-07-8
C₂₁H₃₂O₃

: 1606163-21-6
8-α-vinyl-13-α-{4-[2-(2-oxy-3-phenylsulfonyl-1,2,5-oxadiazol-4-oxy)butynoxy]-succinyl}-oximethylene-isosteviol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / ethanol / 1 h

2: dmap / dichloromethane / 12 h / Reflux

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 6 h / 20 °C

With dmap; sodium tetrahydroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2014.03.004

Reference yield:

: 1606163-08-9
8-α-vinyl-13-α-hydroxymethyl-isosteviol

: 1606163-21-6
8-α-vinyl-13-α-{4-[2-(2-oxy-3-phenylsulfonyl-1,2,5-oxadiazol-4-oxy)butynoxy]-succinyl}-oximethylene-isosteviol

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / dichloromethane / 12 h / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 6 h / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/j.bmcl.2014.03.004