3-(2,3,5-Tri-O-benzyl-β-D-arabinofuranosyl)-5-aminopyrazolo<4,3-d>pyrimidine-7-thione

Base Information

Chemical Name:3-(2,3,5-Tri-O-benzyl-β-D-arabinofuranosyl)-5-aminopyrazolo<4,3-d>pyrimidine-7-thione
CAS No.:88287-87-0
Molecular Formula:C₃₁H₃₁N₅O₄S
Molecular Weight:569.684
Hs Code.:

Synonyms:3-(2,3,5-Tri-O-benzyl-β-D-arabinofuranosyl)-5-aminopyrazolo<4,3-d>pyrimidine-7-thione

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Chemical Property of 3-(2,3,5-Tri-O-benzyl-β-D-arabinofuranosyl)-5-aminopyrazolo<4,3-d>pyrimidine-7-thione

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Technology Process of 3-(2,3,5-Tri-O-benzyl-β-D-arabinofuranosyl)-5-aminopyrazolo<4,3-d>pyrimidine-7-thione

There total 11 articles about 3-(2,3,5-Tri-O-benzyl-β-D-arabinofuranosyl)-5-aminopyrazolo<4,3-d>pyrimidine-7-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88287-85-8
N-[3-((2S,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-7-thioxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-benzamide

: 88287-87-0
3-(2,3,5-Tri-O-benzyl-β-D-arabinofuranosyl)-5-aminopyrazolo<4,3-d>pyrimidine-7-thione

Guidance literature:: With sodium hydroxide; In methanol; water; at 100 ℃; Yield given;
DOI:10.1021/jo00177a028

Reference yield:

: 88287-75-6
3-(2,3,5-Tri-O-benzyl-β-D-arabinofuranosyl)-4-<<(2,2,2-trichlorethoxy)carbonyl>amino>pyrazole-5-carbonitrile

: 88287-87-0
3-(2,3,5-Tri-O-benzyl-β-D-arabinofuranosyl)-5-aminopyrazolo<4,3-d>pyrimidine-7-thione

Guidance literature:: Multi-step reaction with 5 steps

1: Zn, NH₄Cl / methanol / Heating

2: H₂S, triethylamine / pyridine

3: pyridine / toluene / 1.) 0 deg C, 2.) room temp.

4: NH₄OH / methanol / 100 °C

5: NaOH / methanol; H₂O / 100 °C

With pyridine; ammonium hydroxide; sodium hydroxide; hydrogen sulfide; ammonium chloride; triethylamine; zinc; In pyridine; methanol; water; toluene;
DOI:10.1021/jo00177a028

Reference yield:

: 88287-73-4
3-(2,3,5-Tri-O-benzyl-β-D-arabinofuranosyl)-5-cyanopyrazole-4-carboxylic acid

: 88287-87-0
3-(2,3,5-Tri-O-benzyl-β-D-arabinofuranosyl)-5-aminopyrazolo<4,3-d>pyrimidine-7-thione

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / diphenyl phosphoryl azide, triethylamine / toluene / Heating

2: Zn, NH₄Cl / methanol / Heating

3: H₂S, triethylamine / pyridine

4: pyridine / toluene / 1.) 0 deg C, 2.) room temp.

5: NH₄OH / methanol / 100 °C

6: NaOH / methanol; H₂O / 100 °C

With pyridine; ammonium hydroxide; sodium hydroxide; diphenyl phosphoryl azide; hydrogen sulfide; ammonium chloride; triethylamine; zinc; In pyridine; methanol; water; toluene;
DOI:10.1021/jo00177a028