Technology Process of (E)-N'-[3-(4-trifluoromethoxyphenyl)propenoyl]isonicotinohydrazide
There total 3 articles about (E)-N'-[3-(4-trifluoromethoxyphenyl)propenoyl]isonicotinohydrazide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 24h;
DOI:10.1021/jm101510d
- Guidance literature:
-
Multi-step reaction with 2 steps
1: water; potassium carbonate / methanol / 3 h / Reflux
2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C
With
water; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm101510d
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere
1.2: 20 h / 25 °C / Inert atmosphere
2.1: water; potassium carbonate / methanol / 3 h / Reflux
3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C
With
water; sodium hydride; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
1.1: Horner-Wadsworth-Emmons olefination / 1.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm101510d
