tert-butyl 7-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

Base Information

Chemical Name:tert-butyl 7-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate
CAS No.:1338219-63-8
Molecular Formula:C₁₃H₁₈N₂O₃
Molecular Weight:250.298
Hs Code.:

Synonyms:tert-butyl 7-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

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Chemical Property of tert-butyl 7-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

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Technology Process of tert-butyl 7-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

There total 1 articles about tert-butyl 7-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20265-38-7
3-amino-2-methoxypyridine

: 1338219-63-8
tert-butyl 7-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,4-dioxane / 4 h / Reflux

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / diethyl ether; hexane / -78 - -15 °C

2.2: -70 - 20 °C

2.3: 0 °C

3.1: triethylamine / dichloromethane / 0 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; dichloromethane;
DOI:10.1016/j.tetlet.2011.08.009

Reference yield:

: 1338219-63-8
tert-butyl 7-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

: 1338219-67-2
2,3-dihydro-1H-pyrrolo[2,3-c]pyridin-7-yl(phenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium thiomethoxide / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

2.1: trichlorophosphate / N,N-dimethyl-formamide; toluene / 7 h / 90 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 130 °C

4.1: tetrahydrofuran / -5 - 20 °C

4.2: pH 1

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trichlorophosphate; sodium thiomethoxide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetlet.2011.08.009

Reference yield:

: 1338219-63-8
tert-butyl 7-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

: 1338219-65-0
7-chloro-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium thiomethoxide / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

2: trichlorophosphate / N,N-dimethyl-formamide; toluene / 7 h / 90 °C

With trichlorophosphate; sodium thiomethoxide; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetlet.2011.08.009