N-(2-methyl-4-piperidin-4-yl-5-trifluoromethylbenzoyl)-N'-(carbobenzyloxy)guanidine hydrochloride

Base Information

Chemical Name:N-(2-methyl-4-piperidin-4-yl-5-trifluoromethylbenzoyl)-N'-(carbobenzyloxy)guanidine hydrochloride
CAS No.:1204331-10-1
Molecular Formula:C₂₃H₂₅F₃N₄O₃*ClH
Molecular Weight:498.933
Hs Code.:

Synonyms:N-(2-methyl-4-piperidin-4-yl-5-trifluoromethylbenzoyl)-N'-(carbobenzyloxy)guanidine hydrochloride

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Chemical Property of N-(2-methyl-4-piperidin-4-yl-5-trifluoromethylbenzoyl)-N'-(carbobenzyloxy)guanidine hydrochloride

Chemical Property:

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Technology Process of N-(2-methyl-4-piperidin-4-yl-5-trifluoromethylbenzoyl)-N'-(carbobenzyloxy)guanidine hydrochloride

There total 6 articles about N-(2-methyl-4-piperidin-4-yl-5-trifluoromethylbenzoyl)-N'-(carbobenzyloxy)guanidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1204331-09-8
4-[5-methyl-4-(N-(carbobenzyloxy)guanidinocarbonyl)-2-trifluoromethylphenyl]piperidine-1-carboxylic acid tert-butyl ester

: 1204331-10-1
N-(2-methyl-4-piperidin-4-yl-5-trifluoromethylbenzoyl)-N'-(carbobenzyloxy)guanidine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 6h;
DOI:10.1021/jm300601d

Reference yield:

: 340158-54-5
4-hydroxy-5-iodo-2-methyl-benzoic acid methyl ester

: 1204331-10-1
N-(2-methyl-4-piperidin-4-yl-5-trifluoromethylbenzoyl)-N'-(carbobenzyloxy)guanidine hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

2.1: copper(l) iodide / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C

3.1: hydrogen; 10% Pd/C / ethanol / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; N,N-phenylbistrifluoromethane-sulfonimide / N,N-dimethyl-formamide / 20 °C

4.2: 0.5 h / 110 °C / Microwave irradiation

5.1: hydrogen; 10% Pd/C / ethanol / Inert atmosphere

6.1: lithium hydroxide monohydrate / methanol; water / 40 °C

6.2: pH 5

7.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C

7.2: 20 °C

8.1: hydrogenchloride / methanol; 1,4-dioxane / 6 h / 20 °C

With hydrogenchloride; copper(l) iodide; N,N-phenylbistrifluoromethane-sulfonimide; lithium hydroxide monohydrate; 10% Pd/C; 2-chloro-1-methyl-pyridinium iodide; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; water; N,N-dimethyl-formamide; 4.2: |Suzuki Coupling;
DOI:10.1021/jm300601d

Reference yield:

: 213332-65-1
4-hydroxy-2-methyl-5-trifluoromethylbenzoic acid methyl ester

: 1204331-10-1
N-(2-methyl-4-piperidin-4-yl-5-trifluoromethylbenzoyl)-N'-(carbobenzyloxy)guanidine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; N,N-phenylbistrifluoromethane-sulfonimide / N,N-dimethyl-formamide / 20 °C

1.2: 0.5 h / 110 °C / Microwave irradiation

2.1: hydrogen; 10% Pd/C / ethanol / Inert atmosphere

3.1: lithium hydroxide monohydrate / methanol; water / 40 °C

3.2: pH 5

4.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C

4.2: 20 °C

5.1: hydrogenchloride / methanol; 1,4-dioxane / 6 h / 20 °C

With hydrogenchloride; N,N-phenylbistrifluoromethane-sulfonimide; lithium hydroxide monohydrate; 10% Pd/C; 2-chloro-1-methyl-pyridinium iodide; hydrogen; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; water; N,N-dimethyl-formamide; 1.2: |Suzuki Coupling;
DOI:10.1021/jm300601d