(1R,2S,7R,9R,11R,12S)-12-Benzyloxy-11-dimethylcarbamoyl-5-methyl-1-vinyl-8-oxa-tricyclo[7.2.1.0^2,7]dodec-4-ene-2-carboxylic acid methyl ester

Base Information

• Chemical Name: (1R,2S,7R,9R,11R,12S)-12-Benzyloxy-11-dimethylcarbamoyl-5-methyl-1-vinyl-8-oxa-tricyclo[7.2.1.0^2,7]dodec-4-ene-2-carboxylic acid methyl ester
• CAS No.: 98875-20-8
• Molecular Formula: C₂₆H₃₃NO₅
• Molecular Weight: 439.552

Synonyms:(1R,2S,7R,9R,11R,12S)-12-Benzyloxy-11-dimethylcarbamoyl-5-methyl-1-vinyl-8-oxa-tricyclo[7.2.1.0^2,7]dodec-4-ene-2-carboxylic acid methyl ester

Chemical Property of (1R,2S,7R,9R,11R,12S)-12-Benzyloxy-11-dimethylcarbamoyl-5-methyl-1-vinyl-8-oxa-tricyclo[7.2.1.0^2,7]dodec-4-ene-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,7R,9R,11R,12S)-12-Benzyloxy-11-dimethylcarbamoyl-5-methyl-1-vinyl-8-oxa-tricyclo[7.2.1.0^2,7]dodec-4-ene-2-carboxylic acid methyl ester

There total 13 articles about (1R,2S,7R,9R,11R,12S)-12-Benzyloxy-11-dimethylcarbamoyl-5-methyl-1-vinyl-8-oxa-tricyclo[7.2.1.0^2,7]dodec-4-ene-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3R,4aR,8aR)-3-Hydroxy-2-hydroxymethyl-7-methyl-4-oxo-3,4,8,8a-tetrahydro-2H,5H-chromene-4a-carboxylic acid methyl ester (98875-28-6) → (1R,2S,7R,9R,11R,12S)-12-Benzyloxy-11-dimethylcarbamoyl-5-methyl-1-vinyl-8-oxa-tricyclo[7.2.1.02,7]dodec-4-ene-2-carboxylic acid methyl ester (98875-20-8)

Guidance literature:

Multi-step reaction with 10 steps

1: camphorsulfonic acid (CSA)

2: 95 percent / tetrahydrofuran

3: SOCl₂, pyridine / tetrahydrofuran

4: dimethylformamide

5: NaOMe / methanol

6: 88 percent / toluene / Heating

7: camphorsulfonic acid (CSA), MeOH

8: 83 percent / pyridine

9: KN(Me₃Si)2 / tetrahydrofuran / -78 - 25 °C

With pyridine; methanol; thionyl chloride; camphor-10-sulfonic acid; sodium methylate; potassium hexamethylsilazane; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jo00223a053

Reference yield:

(2R,3S,4S,4aS,8aR)-4-Dimethylcarbamoylmethyl-3-hydroxy-2-hydroxymethyl-7-methyl-4-vinyl-3,4,8,8a-tetrahydro-2H,5H-chromene-4a-carboxylic acid methyl ester (98875-29-7) → (1R,2S,7R,9R,11R,12S)-12-Benzyloxy-11-dimethylcarbamoyl-5-methyl-1-vinyl-8-oxa-tricyclo[7.2.1.02,7]dodec-4-ene-2-carboxylic acid methyl ester (98875-20-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / pyridine

2: KN(Me₃Si)2 / tetrahydrofuran / -78 - 25 °C

With pyridine; potassium hexamethylsilazane; In tetrahydrofuran;

DOI:10.1021/jo00223a053

Reference yield:

(4aR,8aR,9aR,10aR)-6-Methyl-9-oxo-2-phenyl-4,4a,5,9,9a,10a-hexahydro-8H-1,3,10-trioxa-anthracene-8a-carboxylic acid methyl ester → (1R,2S,7R,9R,11R,12S)-12-Benzyloxy-11-dimethylcarbamoyl-5-methyl-1-vinyl-8-oxa-tricyclo[7.2.1.02,7]dodec-4-ene-2-carboxylic acid methyl ester (98875-20-8)

Guidance literature:

Multi-step reaction with 9 steps

1: 95 percent / tetrahydrofuran

2: SOCl₂, pyridine / tetrahydrofuran

3: dimethylformamide

4: NaOMe / methanol

5: 88 percent / toluene / Heating

6: camphorsulfonic acid (CSA), MeOH

7: 83 percent / pyridine

8: KN(Me₃Si)2 / tetrahydrofuran / -78 - 25 °C

With pyridine; methanol; thionyl chloride; camphor-10-sulfonic acid; sodium methylate; potassium hexamethylsilazane; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jo00223a053

upstream raw materials:

benzyl bromide

(1R,2S,7R,9R,11R,12S)-11-Dimethylcarbamoyl-12-hydroxy-5-methyl-1-vinyl-8-oxa-tricyclo[7.2.1.0^2,7]dodec-4-ene-2-carboxylic acid methyl ester

(2R,3R,4aR,8aR)-3-Hydroxy-2-hydroxymethyl-7-methyl-4-oxo-3,4,8,8a-tetrahydro-2H,5H-chromene-4a-carboxylic acid methyl ester

(2R,3S,4S,4aS,8aR)-4-Dimethylcarbamoylmethyl-3-hydroxy-2-hydroxymethyl-7-methyl-4-vinyl-3,4,8,8a-tetrahydro-2H,5H-chromene-4a-carboxylic acid methyl ester

Downstream raw materials:

(1R,2S,7R,9R,11R,12S)-11-Acetyl-12-benzyloxy-5-methyl-1-vinyl-8-oxa-tricyclo[7.2.1.0^2,7]dodec-4-ene-2-carboxylic acid methyl ester

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