ACETAMINOPHEN GLUCURONIDE SODIUM SALT

Base Information

• Chemical Name: ACETAMINOPHEN GLUCURONIDE SODIUM SALT
• CAS No.: 120595-80-4
• Molecular Formula: C14H16NNaO8
• Molecular Weight: 349.273
• Hs Code.: 29329990
• Mol file: 120595-80-4.mol

Synonyms:ACETAMINOPHEN GLUCURONIDE SODIUM SALT; Acetaminophen glucuronide Paracetamol glucuronide; Acetaminophen glucuronide,Paracetamol glucuronide;

Chemical Property of ACETAMINOPHEN GLUCURONIDE SODIUM SALT

Chemical Property:

• Appearance/Colour: Off-white cyrstalline solid
• Melting Point: 232-233 °C (dec)
• PSA: 148.38000
• LogP: -2.34570
• Storage Temp.: −20°C
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

4-Acetamidophenyl b-D-glucuronide sodium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: The major urinary metabolite of Acetaminophen (A161220) in man. The major urinary metabolite of Acetaminophen (A161220) (Paracetamol) in man. The major urinary metabolite of acetaminophen in man

Technology Process of ACETAMINOPHEN GLUCURONIDE SODIUM SALT

There total 3 articles about ACETAMINOPHEN GLUCURONIDE SODIUM SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl <4-(acetamido)phenyl 2,3,4-tri-O-acetyl-β-D-glucopyranosid>uronate (30824-21-6) → 1-O-(4-acetamidophenyl)-β-D-glucopyranuronic acid sodium salt (120595-80-4)

Guidance literature:

methyl <4-(acetamido)phenyl 2,3,4-tri-O-acetyl-β-D-glucopyranosid>uronate; With water; In tetrahydrofuran; methanol; at 0 ℃; Inert atmosphere;

With potassium carbonate; In tetrahydrofuran; methanol; at 40 ℃; for 5h; Further stages; Inert atmosphere;

DOI:10.1016/j.carres.2011.12.018

Reference yield:

methyl 2,3,4-tri-O-acetyl-D-glucopyranuronate (72692-06-9,73464-50-3,3082-95-9) → 1-O-(4-acetamidophenyl)-β-D-glucopyranuronic acid sodium salt (120595-80-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dichloromethane / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: dichloromethane / 0.5 h / Molecular sieve

2.2: 0 °C

3.1: water / tetrahydrofuran; methanol / 0 °C / Inert atmosphere

3.2: 5 h / 40 °C / Inert atmosphere

With water; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.carres.2011.12.018

Reference yield:

methyl 2,3,4-tri-O-acetyl-1-O-(trichloroacetimidoyl)-α-D-glucopyranuronate (92420-89-8) → 1-O-(4-acetamidophenyl)-β-D-glucopyranuronic acid sodium salt (120595-80-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 0.5 h / Molecular sieve

1.2: 0 °C

2.1: water / tetrahydrofuran; methanol / 0 °C / Inert atmosphere

2.2: 5 h / 40 °C / Inert atmosphere

With water; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.carres.2011.12.018

upstream raw materials:

methyl 2,3,4-tri-O-acetyl-D-glucopyranuronate

methyl 2,3,4-tri-O-acetyl-1-O-(trichloroacetimidoyl)-α-D-glucopyranuronate

methyl <4-(acetamido)phenyl 2,3,4-tri-O-acetyl-β-D-glucopyranosid>uronate