Probenecid Acyl -D-Glucuronide

Base Information

• Chemical Name: Probenecid Acyl -D-Glucuronide
• CAS No.: 34017-15-7
• Molecular Formula: C19H27 N O10 S
• Molecular Weight: 461.49
• Hs Code.: 2938909090
• Mol file: 34017-15-7.mol

Synonyms:Glucopyranuronicacid, 1-[p-(dipropylsulfamoyl)benzoate], b-D- (6CI,8CI); Probenecid glucuronide

Chemical Property of Probenecid Acyl -D-Glucuronide

Chemical Property:

• Vapor Pressure: 6.87E-20mmHg at 25°C
• Melting Point: 153-160?C
• Boiling Point: 688.3°Cat760mmHg
• PKA: 2.65±0.70(Predicted)
• Flash Point: 370°C
• PSA: 199.51000
• Density: 1.49g/cm³
• LogP: 0.34320
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

ProbenecidAcylβ-D-Glucuronide>90% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: The major metabolite of Probenecid (P755000). The major metabolite of Probenecid.

Technology Process of Probenecid Acyl -D-Glucuronide

There total 2 articles about Probenecid Acyl -D-Glucuronide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 2,3,4-tri-O-benzyl-1-O-[p-(dipropylsulfamoyl)benzoyl]-β-D-glucopyranuronate → Probenecid glucuronide (34017-15-7)

Guidance literature:

With hydrogen;

DOI:10.1021/tx010166t

Reference yield:

3-O-[p-(dipropylsulfamoyl)benzoyl]-D-glucopyranuronic acid → Probenecid glucuronide (34017-15-7) + 2-O-[p-(dipropylsulfamoyl)benzoyl]-D-glucopyranuronic acid + 4-O-[p-(dipropylsulfamoyl)benzoyl]-D-glucopyranuronic acid + 1-O-[p-(dipropylsulfamoyl)benzoyl]-α-D-glucopyranuronic acid

Guidance literature:

With sodium phosphate buffer; In water; acetonitrile; at 37 ℃; pH=7.4; Further Variations:; Reagents; pH-values; Product distribution; Kinetics;

DOI:10.1021/tx010166t

Reference yield:

Probenecid glucuronide (34017-15-7) → 4-[(dipropylamino)sulfonyl]benzoic acid (57-66-9) + 3-O-[p-(dipropylsulfamoyl)benzoyl]-D-glucopyranuronic acid + 2-O-[p-(dipropylsulfamoyl)benzoyl]-D-glucopyranuronic acid + 4-O-[p-(dipropylsulfamoyl)benzoyl]-D-glucopyranuronic acid

Guidance literature:

With sodium phosphate buffer; In water; acetonitrile; at 37 ℃; pH=7.4; Further Variations:; Reagents; pH-values; Product distribution; Kinetics;

DOI:10.1021/tx010166t

Downstream raw materials:

4-[(dipropylamino)sulfonyl]benzoic acid

Refernces