2-Fluoro-4-methylpyridin-3-amine

Base Information

• Chemical Name: 2-Fluoro-4-methylpyridin-3-amine
• CAS No.: 173435-32-0
• Molecular Formula: C₆H₇FN₂
• Molecular Weight: 126.133
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID20376774
• Wikidata: Q72437233
• Mol file: 173435-32-0.mol

Synonyms:2-fluoro-4-methylpyridin-3-amine;173435-32-0;3-Amino-2-fluoro-4-picoline;3-AMINO-2-FLUORO-4-METHYLPYRIDINE;3-PYRIDINAMINE, 2-FLUORO-4-METHYL-;2-Fluoro-4-methyl-pyridin-3-ylamine;SCHEMBL7849737;DTXSID20376774;ZKQQKPXTKXTEQR-UHFFFAOYSA-N;MFCD04112556;AKOS006342461;AB17625;AM62419;CS-W021693;DS-11263;FT-0645923;EN300-1295268;A811513;J-010905

Chemical Property of 2-Fluoro-4-methylpyridin-3-amine

Chemical Property:

• Melting Point: 63-64℃
• Boiling Point: 260.8 °C at 760 mmHg
• PKA: 1.16±0.18(Predicted)
• Flash Point: 111.5 °C
• PSA: 38.91000
• Density: 1.196 g/cm³
• LogP: 1.69250
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 126.05932639
• Heavy Atom Count: 9
• Complexity: 97.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Fluoro-4-methylpyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=NC=C1)F)N
• Uses: 2-Fluoro-4-methylpyridin-3-amine is auseful reactant in the synthesis of phenylsulfonamidomethylbenzamides, oxopyridopyrrolopyrazinyacetamides, carbamoylalkylthiophenylmethylpicolinamides and benzylthiotriazolylpyridines, which exhibit SAR and kappa opioid receptor agonistic and antagonistic activity.

Technology Process of 2-Fluoro-4-methylpyridin-3-amine

There total 2 articles about 2-Fluoro-4-methylpyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoro-4-methyl-3-nitropyridine (19346-43-1) → 3-Amino-2-fluoro-4-methylpyridine (173435-32-0)

Guidance literature:

With acetic acid; palladium; In ethyl acetate;

Reference yield:

→ 3-Amino-2-fluoro-4-methylpyridine (173435-32-0)

Guidance literature:

Reference yield:

3-Amino-2-fluoro-4-methylpyridine (173435-32-0) → ML 190 (1355244-02-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: acetic acid / 2 h / Reflux

2.1: ammonia / 2 h / 150 °C / Sealed tube

3.1: toluene / 3 h / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 16 h

5.1: lithium hydroxide / tetrahydrofuran; methanol; water / 16 h / 20 °C

5.2: pH 3

6.1: dmap; diisopropyl-carbodiimide / 16 h / 20 °C

With dmap; ammonia; sodium hydride; acetic acid; lithium hydroxide; diisopropyl-carbodiimide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;

upstream raw materials:

2-fluoro-4-methyl-3-nitropyridine

Downstream raw materials:

ML 190

Refernces

• 1、 -. "N-pyridinyl[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide herbicides". . . Retrieved 2008/06/13.
• 2、 -. "N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides". . . Retrieved 2008/06/13.