Technology Process of (+/-)-α-(acetylamino)-4-<<2-(1,1-dimethylethyl)-2H-tetrazol-5-yl>methyl>benzenepropanoic acid
There total 9 articles about (+/-)-α-(acetylamino)-4-<<2-(1,1-dimethylethyl)-2H-tetrazol-5-yl>methyl>benzenepropanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethanol;
Ambient temperature;
DOI:10.1021/jm00107a037
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 44 percent / NaN3, NH4Cl / dimethylformamide / 48 h / 90 °C
2: 54 percent / conc. H2SO4 / trifluoroacetic acid / 24 h
3: 49 percent / Ph3P, tributylamine, tert-BuOH, bis(triphenylphosphinepalladium)dichloride / 48 h / 100 °C / 10343 Torr
4: 70 percent / diisobutylaluminium hydride (DIBAL) / toluene / 0 - 20 °C
5: 54 percent / Ph3P, CBr4 / diethyl ether / 3 h
6: 50 percent / 10percent aq. NaOH / tetrabutyl ammonium sulfate / CH2Cl2 / 5 h / Ambient temperature
7: 67 percent / acetonitrile; H2O / 2 h / Ambient temperature
8: 69 percent / Et3N / CH2Cl2 / 2 h
9: 76 percent / H2 / 10percent Pd/C / ethanol / Ambient temperature
With
bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; sodium azide; tributyl-amine; carbon tetrabromide; sulfuric acid; hydrogen; diisobutylaluminium hydride; ammonium chloride; triethylamine; triphenylphosphine; tert-butyl alcohol;
palladium on activated charcoal; tetra(n-butyl)ammonium hydrogensulfate;
In
diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; trifluoroacetic acid;
DOI:10.1021/jm00107a037
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 54 percent / conc. H2SO4 / trifluoroacetic acid / 24 h
2: 49 percent / Ph3P, tributylamine, tert-BuOH, bis(triphenylphosphinepalladium)dichloride / 48 h / 100 °C / 10343 Torr
3: 70 percent / diisobutylaluminium hydride (DIBAL) / toluene / 0 - 20 °C
4: 54 percent / Ph3P, CBr4 / diethyl ether / 3 h
5: 50 percent / 10percent aq. NaOH / tetrabutyl ammonium sulfate / CH2Cl2 / 5 h / Ambient temperature
6: 67 percent / acetonitrile; H2O / 2 h / Ambient temperature
7: 69 percent / Et3N / CH2Cl2 / 2 h
8: 76 percent / H2 / 10percent Pd/C / ethanol / Ambient temperature
With
bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; tributyl-amine; carbon tetrabromide; sulfuric acid; hydrogen; diisobutylaluminium hydride; triethylamine; triphenylphosphine; tert-butyl alcohol;
palladium on activated charcoal; tetra(n-butyl)ammonium hydrogensulfate;
In
diethyl ether; ethanol; dichloromethane; water; toluene; acetonitrile; trifluoroacetic acid;
DOI:10.1021/jm00107a037
